Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology - Unit 1 - Zach H. > Lecture 3: Leukocyte Circulation and Migration into Tissue > Flashcards

Lecture 3: Leukocyte Circulation and Migration into Tissue Flashcards

1
Q

What is recirculation the ability of lymphocytes to repeatedly do?

A

1) home to secondary lymphoid organs
2) reside there transiently
3) return to the blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is leukocyte homing?

A

Cell migration out of the blood and into peripheral tissues, or to a site of an infection or injury.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is a major part of inflammation?

A

Recruitment of leukocytes and plasma proteins from the blood to sites of infection and tissue injury.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Does inflammation cause tissue damage?

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the 4 steps in the cascade of adhesive and activation events in leukocyte recruitment?

A

1) tethering
2) rolling
3) adhesion and stop
4) transmigration in to the tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is tethering?

A

occurs through transient interactions of selectins and integrins with their ligands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is rolling?

A

allows chemokine receptors on leukocytes to bind chemokines expressed on endothelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is adhesion and stop?

A

Receptors signal and activate integrins on leukocytes which interact with ligands expressed on endothelium and trigger adhesion to the endothelium.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is transmigration in to the tissue?

A

Leukocyte then transmigrate into the extravascular space where they can migrate down chemokine gradients towards specific areas.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Do endothelial cells in healthy tissues express adhesion molecules on their surfaces facing the blood?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What activates the endothelial cells at sites of infection and tissue injury to express adhesion molecules?

A

cytokines secreted by resident immune cells at these sites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Fill in the Blank:

Homin involves molecules on the surfaces of both the leukocyte (_________________) and endothelial cells (______).

A

homing receptors and chemokine receptors; chemokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are addressins?

A

comprise a set of several adhesion molecules on the surface of endothelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the 3 types of selectins?

A

P-selectin (CD62P)
E-selectin (CD62E)
L-selectin (CD62L)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What type of selectin is expressed on endothelium activated by histamine or thrombin?

A

P-selectin (CD62P)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the ligand molecule for P-selectin?

A

Sialyl Lewis X on PSGL-1 and other glycoproteins

17
Q

What causes the expression of E-selectin (CD62E) on endothelium?

A

activated by cytokines TNF and IL-1

18
Q

What causes the expression of L-selectin (CD62L) on endothelium?

A

neutrophils, monocytes, T cells (naive and central memory), B cells (naive)

19
Q

What cell types express the ligand that binds to P-selectin?

A

neutrophils
monocytes
T cells (effector, memory)

20
Q

What is the ligand molecule for E-selectin?

A

Sialyl Lewis X (e.g., CLA-1) on glycoproteins

21
Q

What cell types express the ligand that binds to E-selectin?

A

neutrophils
monocytes
T cells (effector, memory)

22
Q

What ligand molecule binds to L-selectin?

A

Sialyl Lewis X/PNAd on GlyCAM-1, CD34, MadCAM-1, others

23
Q

What cell types express the ligand that binds to L-selectin?

A

endothelium (HEV)

24
Q

Which cell type expresses P-selectin and E-selectin?

A

endothelial cells

25
Q

True or False:

E-selectin is synthesized and expressed on the endothlial cell surface within 1 to 2 hours in response to the cytokines IL-1 and TNF produced by tissue macrophages in response to infection.

A

True

26
Q

Is L-selectin expressed on endothelial cells?

A

No - expressed on leukocytes and lymphocytes

27
Q

What is another name for L-selectin ligands expressed on HEV?

A

peripheral node addressins (PNAd)

28
Q

What cells express LFA-1 integrins?

A

neutrophils
monocytes
T cells (naive, effector, memory)
B cells (naive)

29
Q

What cells express Mac-1 integrins?

A

neutrophils
monocytes
dendritic cells

30
Q

What cells express VLA-4 integrins?

A 
monocytes 
T cells (naive, effector, memory)
31
Q

What cells express alpha 4 beta 7 integrins?

A 
monocytes 
T cells (gut homing, naive, effector, memory)
B cells (gut homing)
32
Q

What ligand molecules bind to LFA-1 and Mac-1 integrins?

A

ICAM-1 (CD54)

ICAM-2 (CD102)

33
Q

What type of cell expresses ligands ICAM1 and ICAM2?

A

endothelium (cytokine induced)

34
Q

What ligand molecule binds to VLA-4 and alpha4beta7?

A

VCAM-1 (CD106)

MadCAM-1 also binds to alpha4beta7

35
Q

Which cell type expresses VCAM-1 (CD106)

A

endothelium (cytokine-induced)

endothelium in gut and gut-associated lymphoid tissues

36
Q

In what type of endothelium is MadCAM-1 expressed?

A

endothelium in gut and gut-associated lymphoid tissues

Immunology - Unit 1 - Zach H. (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions