Chemokines

Question 1

CCL2

Answer 1

Function –> mixed leukocyte recuitment (monocytes)

Original Name –> MCP-1

Chemokine Receptor –> CCR2

Question 2

CCL19

Answer 2

Function –> T cell and DC migration into parafollicular zones of LN

Original Name –> MIP-3beta

Chemokine receptor –> CCR7

Question 3

CCL21

Answer 3

Function –> T cell and DC migration in parafollicular zones of LN.

Original Name –> SLC

Chemokine Receptor –> CCR7

Question 4

CXCL 8

Answer 4

neutrophil recruitment

• IL-8 *

Question 5

CXCL10

Answer 5

effector T cell recruitment

• IP-10 *

Question 6

CXCL12

Answer 6

homing naive B cells to LNs

• SDF-1 alpha beta *

Question 7

CXCL13

Answer 7

B cell migration into follicles; T follicular helper cell migration into follicles

• BCA-1 *

Question 8

Which chemokines are displayed on the surface of the HEV?

Answer 8

CCL19 and CCL21

Question 9

Ag-activated T cells have low levels of what protein, and thus stay in the LN?

Answer 9

S1PR1

Question 10

What is re-expressed after several days and activated and differentated effector T cells then sense the S1P gradient and exit the node?

Answer 10

S1PR1

Question 11

Migration of effector T cells into peripheral tissue is mediated by what?

Answer 11

E-selectin
P-selectin
CXCL10