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Residency Boards > TM > Flashcards

TM Flashcards

1
Q

How many platelets in a pheresis unit?

A

3 x10^11

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2
Q

Minimum donor intervals RBC

A

> =8 weeks for single unit whole blood donation

16 weeks if double unit by apheresis

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3
Q

bombay phenotype

A

Lacks H and secretor genes (hh, sese)

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4
Q

What sugar makes A antigen

A

Gal-NAc (N-acetylgalactosamine)

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5
Q

What sugar makes B antigen?

A

galactose (Gal)

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6
Q

what minor red cell antibody is most common cause of ABO discrepancy?

A

Anti-M (IgM)

*Redo ABO testing with M neg cells

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7
Q

What infection associated with Anti-I autoantibody?

A

Mycoplasma pneumonia

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8
Q

What infection associated with anti-i autoantibody?

A

infectious mononucleosis

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9
Q

PCH caused by what antibody?

A

Auto anti-P

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10
Q

Most common Weiner haplotype in caucasians?

A

R1 DCe

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11
Q

Most common Weiner haplotype in african americans?

A

R0 Dce

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12
Q

duffy negative confers resistance to what?

A

P. vivax

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13
Q

3 possibilities of RhD+ person showing anti-D?

A
  1. Variant/partial D (weak D testing will pick up)
  2. Auto-antibody (DAT +)
  3. Anti-LW antibody (DAT -)
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14
Q

Which antibodies show dosage

A

Kids, Monkeys (Rh) and MeN Show Dosage

–>Kidd, Rh, MNS and Duffy

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15
Q

Which antibody shows anamnestic response?

A

Kidd system (kids hide)

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16
Q

Which antibodies are enhanced by enyzmes?

A

Give sugar (CHO antigens) to Kids and monkeys (Rh) and they will jump

Rh
Kidd
Le, I, P, ABO

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17
Q

Which antibodies are decreased by enyzmes?

A

Daffy MeNS Lutheran Choir falls down

Duffy
MNS
Lu
Chido-Rogers

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18
Q

Which antibodies are unaffected by enyzmes?

A

Kell (doesn’t care)

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19
Q

RBC/Whole blood storage

A 
21 days (CPD/2D)
35 days (CPDA-1)
42 days (AS_
all @1-6C
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20
Q

Frozen RBC storage

A

10 yrs @-65C

24 hrs @1-6C after thaw

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21
Q

Washed RBC storage

A

24 hrs @1-6 C

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22
Q

Platelet storage

A

5 days @20-24 C (gentle agitation)

4 hours if pooled in open system

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23
Q

granulocyte storage

A

24 hrs 20-24C (no agitation)

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24
Q

FFP stroage

A

1 year @-18C
7 years @ -65C
24 hrs at 1-6 C after thaw

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25
Q

Cryo storage

A

1 year @-18C

6 hrs @20-24C after thaw (4 hours in pooled open system)

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26
Q

RBC quality control

A

HCT <80% all

>50g Hb in 95% (apheresis RBC)

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27
Q

Quality control leukoreduced RBCs

A

<5x10^6 WBCs in 95%, retain 85% of RBCs

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28
Q

Quality control cryo

A

factor 8>80IU, fibrinogen >150 mg

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29
Q

RBC storage lesion

A

Decreased 2,3 DPG
Decreased ATP
Decreased pH
Decreased K+ in red cells, but increased K+ extracellularly

30
Q

Minimum interval for donation apheresis platelet

A

Platelets apheresis <= 2 donations/week at least 2 days apart (<=24 in 12 mo period)

31
Q

What color is Anti-A (ABO typing)?

A

Blue

32
Q

What color is Anti-B (ABO typing)>?

A

yellow

33
Q

Infectious tests required on donor blood

A 
HBsAg 
Anti-HBc
Anti-HCV
HCV NAT
Anti-HIV1/2
HIV1 RNA
Anti-HTLV1
RPR
34
Q

Calculation for how many units to test to find compatible one

A

Frequency Antigen neg blood in population=100-antigen frequency (multiply if multiple abs)

1/ frequency of antigen neg blood

35
Q

Indications for emergent transfusion/exchange transfusion in sickle cell disease

A 
Stroke
Retinal artery occlusion
Splenic sequestration crisis
Acute chest syndrome
Aplastic crisis
Priapism
36
Q

What classes of maternal alloantibodies cause HDFN?

A

IgG1, IgG3 or IgG4

37
Q

Calculate RhIg dose

A

Vials=(maternal blood volume* %fetal cells in maternal blood)/30

If decimal .5 round up and add one

38
Q

Maternal critical tiger for anti-kell

A

1:8

39
Q

Contraindications to platelet transfusion

A

Relative—ITP

Absolute—HIT, TTP

40
Q

how many mg of iron are in one unit (500cc) of whole blood?

A

200 mg

41
Q

optimum CD34+ cell dose needed for hematopoietic recovery after allogenic peripheral blood stem cell transplant

A

2-5 x 10^6 cells/kg

42
Q

optimum CD34+ cell dose needed for hematopoietic recovery after autologous peripheral blood stem cell transplant

A

2x10^8 cells/kg

43
Q

What is the most immunogenic ABO blood group antigen?

A

A1

44
Q

What is the mechanism of TRALI?

A

donor HLA antibodies reacting to recipient leukocytes

45
Q

Whole blood irradiated expiration

A

28 days or original outdate (whichever is sooner)

46
Q

Contents of cryoprecipitate

A

> 150mg fibrinogen and 80 IU factor 8, also has factors 13 and vWF

47
Q

What is dolichos biflorus?

A

Lectin, which has anti-A1 activity and used to distinguish A1 from A2

48
Q

True or false. Recipients with anti-c or anti-e should not be given rh neg blood

A

True. Most common Rh neg genotype is r/r (dce, dce)

49
Q

If anti-E is detected in serum, suspect presence of which other alloantibody?

A

Anti-c

*most with anti-E are R1/R1 (DCe) and have likely been transfused R2 blood (DcE)

50
Q

Antibodies that commonly produce intravascular hemolysis

A

ABO, Kidd, P

51
Q

What cells express HLA class II antigens?

A

B cells, macrophages and activated T cells

52
Q

Causative agents transfusion transmitted sepsis platelets

A

Gram pos, esp staph spp

53
Q

Transfusion transmitted sepsis causative organisms RBCs

A 
Gram neg
Yersinia enterocolitica
Serratia liquifaciens
Citrobacter
Pseudomonas
54
Q

what is evan’s syndrome?

A

WAIHA + ITP

55
Q

What is calculation for patient’s total blood volume?

A

TBV=wt (kg) x 70mL/kg

56
Q

Non-clinically significant alloantibodies

A

lutheran, lewis, M, N, P

57
Q

How long is deferral for etretinate (tegison)?

A

Permanent

58
Q

How long is deferral for acitretin (soriatane)

A

3 yrs

59
Q

How long is deferral for isotretinoin (accutane)

A

30 days

60
Q

How long is deferral for finasteride (proscar, propecia)

A

30 days

61
Q

How long is deferral for dutasteride

A

6 mos

62
Q

What does saliva neutralize?

A

ABO

63
Q

what does hydatid cyst fluid neutralize

A

P1

64
Q

what do pigeon eggs neutralize

A

P1

65
Q

What does urine neutralize

A

Sda

66
Q

What does serum neutralize

A

Chido, Rogers

67
Q

What RBC morphology is associated with intravascular hemolysis

A

Schistocytes

68
Q

What RBC morphology is associated with extra vascular hemolysis

A

Spherocytes

69
Q

What complement components are considered anaphylotoxins

A

C3a and C5a

70
Q

What type of hypersensitivity rxn are allergic TRs?

A

Type 1 IgE mediated

71
Q

What classes of antibodies do not cross the placenta

A

IgG2 and IgM

72
Q

What is ulex europaeus

A

Pectin with H antigen specificity

Residency Boards (9 decks)

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