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Hemepath Flashcards

1
Q

Follicular lymphoma molecular

A

T(14;18) bcl2-IgH

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2
Q

Primary cutaneous follicle center lymphoma (PCFCL) vs nodal follicular lymphoma

A

Most cases PCFCL lack t(14;18) are Bcl6 pos, but Bcl2 and CD10 neg Vs in lymph node FL has t(14;18) and is pos for BCL6, BCL2 and CD10

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3
Q

APL flow

A

CD33+/CD177+/CD34-/HLA-DR-

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4
Q

immunophenotype CLL/SLL

A

B-cell markers: CD19, CD20 (*dim), CD22

CD5+ CD23+

Neg for CD10 Bcl6- FMC-7

*CD38 pos and ZAP-70+=bad prognosis

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5
Q

Immunophenotype mantle cell lymphoma

A

B-cell markers: CD19, CD20 (bright), CD22, FMC-7

CD5+ CD23- Cyclin D1+ CD43+

CD10/Bcl6- Bcl2+

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6
Q

Immunophenotype of follicular lymphoma

A

CD10+ Bcl6+ Bcl2+ (90%)

CD5- CD23-

t(14;18): IgH-Bcl2

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7
Q

Immunophenotype of marginal zone lymphoma

A

B-cell markers; nothing specific

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8
Q

Which two lymphomas express CD25

A

Hairy cell leukemia (also CD20, CD22, TRAP)

Adult T cell leukemia/lymphoma

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9
Q

What lymphoma shows T-cell rosettes?

A

NLP hodgkin lymphoma CD3+ CD57+ T cells surround LP cells forming rosettes

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10
Q

Burkitt lymphoma translocation

A

t(8;14) MYC-IGH

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11
Q

Which 3 lymphomas express CD30?

A
  1. RS cells in HL
  2. ALCL
  3. mediastinal B-cell lymphoma
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12
Q

What distinguishes plasmablastic lymphoma from other plasma cell neoplasms?

A

EBER+

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13
Q

Flow findings in PNH

A
  • RBCs show loss of CD55 and CD59
  • Granulocytes show loss of CD16 and CD24
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14
Q

Which BCR-ABL isoform is associated with CML?

A

p210 isoform of t(9;22) BCR-ABL

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15
Q

Which BCR-ABL isoform is associated with B-ALL?

A

p190 isofrom of t(9;22) BCR-ABL

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16
Q

What subtype of AML is associated with thrombocytosis and giant agranular platelets?

A

AML with inv3

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17
Q

Translocation in acute monocytic leukemia

A

t(8;16) blasts with characteristic cytoplasmic vacuoles

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18
Q
A

Blasts w/ characteristic vacuoles

acute monocytic leukemia t(8;16)

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19
Q

Diagnosis?

A

toxoplasmosis

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20
Q

Favorable prognostic factors B-ALL

A

hyperdiploidy

t(12;21) TEL1-AML

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21
Q

Poor prognostic factors B-ALL

A

Hypodiploidy

t(9;22) BCR-ABL

del17p

t(11q23) MLL rearrangement

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22
Q

What B-cell neoplasm shows clumpy “soccer ball” chromatin on peripheral smear and cytology?

A

CLL/SLL

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23
Q

What translocation is found in mantle cell lymphoma

A

t(11;14) CCND1-IgH

results in cyclin D1 amplification

FISH is best assay

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24
Q

Diagnosis?

A

Marginal zone lymphoma

“monocytoid” lymps w/ abundant clear cytoplasm

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25
Q

Immunophenotype of hairy cell leukemia

A

B-cell markers: CD19, CD20, CD22

CD11c (bright) and CD25 (bright)

cyclin D1 (dim nuclear)

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26
Q

most common lymphomas in HIV infection

A

Burkitt

DLBCL (esp CNS)

Primary effusion lymphoma

, plasmablastic lymphoma

hodgkin lymphoma

27
Q

Subtype of B-ALL/LBL with peripheral blood eosinophilia

A

t(5;14) IL3-IGH

28
Q

What type of lymphoma typically presents as an anterior mediastinal mass often with hypercalcemia?

29
Q

Good prognosis in CLL/SLL

A

normal karyotype or del13q only

mutated status of Ig heavy chain

30
Q

Bad prognosis in CLL/SLL

A

-del11q or 17p

ZAP70 and/or CD38 expression

trisomy 12

lack of somatic hypermutation

31
Q

Langerhans cell histiocytosis is a neoplastic proliferation of which cells?

A

Dendritic cells

32
Q

Diagnosis and immunophenotype

A

follicular dendritic cell sarcoma

CD21(+), CD23(+), CD35(+), often HLA-DR+ and EMA+

10-20% associated with hyaline vascular type castleman disease

33
Q

Wha type of cell is this? What disease is it found in?

A

Hallmark cell

anaplastic large cell lymphoma

34
Q

What cytokine is associated with Castleman disease?

35
Q

Diagnosis

A

Kimura disease

36
Q

what is the precursor lesion of nodular lymphocyte predominant hodgkin lymphoma?

A

progressive transformation of germinal centers

37
Q

What cell type is angioimmunoblastic T-cell lymphoma derived from?

A

CD4+ follicular helper T cells

38
Q

What are the most common T/NK-cell PTLDs?

A

hepatosplenic T-cell lymphoma (**Not EBV associated**)

39
Q

What is diagnosis and immunophenotype?

A

Flower cells

Adult T cell leukemia/lymphoma

CD4+, CD8-,

Also Pos for CD3, CD7, CD25

40
Q

What cell type has birbeck granules?

A

Langerhans cells

41
Q

What causes ATLL (adult T cell leukemia/lymphoma)?

42
Q

What is most commons ite for extraosseus plasmacytoma?

A

Upper respiratory tract (80%)

43
Q

What causes lymphomatous polyposis

A

Mantle cell lymphoma

44
Q

Topoisomerase II therapy related AML is associated with what genetic alteration?

A

11q23 MLL gene abnormalities

45
Q

what translocation is found in gastric and pulmonary MALT lymphomas?

A

t(11;18) API2 and MALT1 genes

46
Q

What condition causes reactive LAD without necrosis and prominent interfollicular plasmacytosis

A

Rheumatoid arthritis

Sjogren syndrome

Still disease

47
Q

Condition causing reactive LAD without necrosis and large germinal centers with dumbbell or serpiginous appearance and thin/absent mantle zone

48
Q

LAD showing paracortical areas expanded by melanin containing histiocytes adn hyperplasia of dendritic and langerhans cells

A

dermatopathic LAD

49
Q

What variant of Castleman disease is associated with systemic disease?

A

plasma cell variant

50
Q

Waldenstrom macroglobulinemia and hyperviscosity syndrome are associated with which type of lymphoma?

A

Lymphoplasmacytic lymphoma

51
Q

What B cell lymphoma shows “monocytoid” B cells

A

marginal zone lymphoma

52
Q

What lymphoma often arises in the oral mucosa of HIV+ patients and consists of immunoblasts expressing MUM1, CD138, EBV but not CD45 or CD20?

A

Plasmablastic subtype of DLBCL

53
Q

Is cutaneous T cell lymphoma and mycosis fungoides a CD4+ or CD8+ lymphoma?

54
Q

What type of RBC is this?

What conditions can cause this?

A

Acanthocytes

Liver disease, abetalipoproteinemia, McLeod phenotype (Kell neg RBCs)

55
Q

What is the first iron index to become abnormal in IDA?

A

Ferritin (decreased)

56
Q

Which subtype of AML with recurrent genetic abnormalities shows marrow basophilia and multilineage dyspoiesis?

A

t(6;9) DEK-NUP24

both children and adults, poor prognosis

57
Q

What is the immunophenotype of LGL?

A

CD2+, CD3+, CD8+

58
Q

What are translocations seen in Burkitt lymphoma?

A

most common t(8;14)

Can be t(2;8)

Amplication of C-MYC on chr8

59
Q

Which marker differentiates adult T-cell leukemia/lymphoma (ATLL) from peripheral T-cell lymphoma (PTCL)?

A

Both are CD4+

ATLL is CD25+ while PTCL is CD25-

60
Q

Favorable cytogenetics in MDS

A

normal karyotype

isolated loss of Y, 5q-, or 20q-

61
Q

Unfavorable cytogenetics in MDS

A

complex karyotype (3+ abnormalities)

abnormalities chromosome 7 (monosomy 7 or 7q-)

62
Q

AML with recurrent genetic abnormalities good prognosis

A

t(8;21) RUNX1

inv16 or t(16;16) MYH11

t(15;17) PML-RARA

63
Q

AML with recurrent genetic abnormalities poor prognosis

A

t(6;9) DEK1-NUP24

inv3 or t(3;3) RPN1-EVI1

Therapy related AML (specifically topo II MLL)

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