Misc AP Flashcards
Minimum # of squamous cells for adequate PAP
Liquid based 5,000
Conventional 8,000-12,000
Meigs syndrome
Triad of ascites, pleural effusion and benign ovarian fibroma
most common malignancy associated with urethral diverticulum?
bladder adenocarcinoma
Subepidermal blisters with predominantly eosinophils
Bullous Pemphigoid
Gestational pemphigoid
Subepidermal blisters with predominantly neutrophils
Dermatitis Herpetiformis
Linear IgA disease
Subepidermal blisters with little or no inflammation
Porphyria Cutanea Tarda
Pseudoporhyria
Tense bullae, subepidermal cleft w/ eos, Linear C3 and IgG at DEJ
Bullous Pemphigoid
skin showing confluent parakeratosis, regular acanthosis with suprapapillary thinning and absence of granular layer
psoriasis
papules on flexor surfaces, elbows and wrists
band-like lymphocytic infiltrate obscuring DEJ, hyperkeratosis, hypergranulosis, irregular acanthosis and colloid bodies
Lichen planus
what conditions result in Serous atrophy of bone marrow?
AIDS, extreme malnutrition/starvation
painful superficial tumors
ANGEL
Angiolipoma, neuroma, glomus tumor, eccrine spiradenoma, leiomyoma
What antibody is present in pemphigus vulgaris?
anti-desmoglein 3 (mucosal)
anti-desmoglein 1 (cutaneous)
Mutations in what gene are found uveal melanoma and blue nevi
GNAQ and GNA11
What precursor is associated with basaloid and warty vulvar carcinomas?
VIN
Liver disease with pos ANA or anti-SMA
Type 1 AIH
Liver disease with pos anti-LKM1
AIH type 2
Liver disease with anti SLA
AIH type 3
Liver disease with antimitochondrial antibodies
PBC
Liver disease with p-ANCA
PSC
What condition is associated with bike ductular cholestasis (inspissated bile concretions within proliferated periportal bile ductular structures)
Sepsis
Causes of microvesicular steatosis
Drugs (anti-retrovirals, tetracycline toxicity, valproic acid)
acute fatty liver of pregnancy
Reye syndrome
5 things that cause granulomas in liver
1-sarcoidosis 2-TB 3-PBC 4-drug hepatotoxicity 5-schistosomiasis
Minimum cellularity anal pap
2000-3000 nucleated squamous cells
What renal neoplasm shows loss of chr1 and Y
Onco and chromo
What renal neoplasm shows trisomy 7 and 17?
Papillary RCC
Two variants of germ cell tumor that occur in testes of prepubertal boys
Yolk sac
Teratoma
What is tested for in urovysion FISH?
aneuploidy for chromosomes 3, 7, 17, and loss of the 9p2
What is Ca 19-9 a marker of?
Pancreas ca
Papillary RCC GENETICS
Loss of Y
Gains of chr7&17
What mutation is found in pilocytic astrocytoma?
BRAF
What genetic abnormality is seen in meningioma?
Monopoly chr22
NF2 gene on chr22
Carney complex
LAMB syndrome
Lentigines, atrial myxoma, myxoid neurofibroma
Mutation in PRKAR1A on chr 17
Carney triad
gastric GIST
Pulmonary chondroma
Extra-adrenal paragangliomA
What 2 molecules are implicated in systemic castelman disease?
IL-6 and VEGF
Translocation in ewing sarcoma
t(11;22) EWSR1-FLI1
What is most accurate evidence for death due to anaphylaxis
serum beta tryptase
follicular cervicitis is associated with what?
Chlamydia trachomatis
Which germ cell tumor shows increased AFP?
Yolk sac
What tumor has schiller-duvall bodies
yolk sac
