Misc AP Flashcards by Danielle Hutchings

Minimum # of squamous cells for adequate PAP

Liquid based 5,000

Conventional 8,000-12,000

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Meigs syndrome

Triad of ascites, pleural effusion and benign ovarian fibroma

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most common malignancy associated with urethral diverticulum?

bladder adenocarcinoma

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Subepidermal blisters with predominantly eosinophils

Bullous Pemphigoid

Gestational pemphigoid

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Subepidermal blisters with predominantly neutrophils

Dermatitis Herpetiformis

Linear IgA disease

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Subepidermal blisters with little or no inflammation

Porphyria Cutanea Tarda

Pseudoporhyria

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Tense bullae, subepidermal cleft w/ eos, Linear C3 and IgG at DEJ

Bullous Pemphigoid

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skin showing confluent parakeratosis, regular acanthosis with suprapapillary thinning and absence of granular layer

psoriasis

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papules on flexor surfaces, elbows and wrists

band-like lymphocytic infiltrate obscuring DEJ, hyperkeratosis, hypergranulosis, irregular acanthosis and colloid bodies

Lichen planus

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what conditions result in Serous atrophy of bone marrow?

AIDS, extreme malnutrition/starvation

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painful superficial tumors

ANGEL

Angiolipoma, neuroma, glomus tumor, eccrine spiradenoma, leiomyoma

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What antibody is present in pemphigus vulgaris?

anti-desmoglein 3 (mucosal)

anti-desmoglein 1 (cutaneous)

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Mutations in what gene are found uveal melanoma and blue nevi

GNAQ and GNA11

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What precursor is associated with basaloid and warty vulvar carcinomas?

VIN

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Liver disease with pos ANA or anti-SMA

Type 1 AIH

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Liver disease with pos anti-LKM1

AIH type 2

Liver disease with anti SLA

AIH type 3

Liver disease with antimitochondrial antibodies

PBC

Liver disease with p-ANCA

PSC

What condition is associated with bike ductular cholestasis (inspissated bile concretions within proliferated periportal bile ductular structures)

Sepsis

Causes of microvesicular steatosis

Drugs (anti-retrovirals, tetracycline toxicity, valproic acid)
acute fatty liver of pregnancy
Reye syndrome

5 things that cause granulomas in liver

1-sarcoidosis
2-TB
3-PBC
4-drug hepatotoxicity
5-schistosomiasis

Minimum cellularity anal pap

2000-3000 nucleated squamous cells

What renal neoplasm shows loss of chr1 and Y

Onco and chromo

What renal neoplasm shows trisomy 7 and 17?

Papillary RCC

Two variants of germ cell tumor that occur in testes of prepubertal boys

Yolk sac | Teratoma

What is tested for in urovysion FISH?

aneuploidy for chromosomes 3, 7, 17, and loss of the 9p2

What is Ca 19-9 a marker of?

Pancreas ca

Papillary RCC GENETICS

Loss of Y | Gains of chr7&17

What mutation is found in pilocytic astrocytoma?

BRAF

What genetic abnormality is seen in meningioma?

Monopoly chr22 | NF2 gene on chr22

Carney complex

LAMB syndrome Lentigines, atrial myxoma, myxoid neurofibroma Mutation in PRKAR1A on chr 17

Carney triad

gastric GIST Pulmonary chondroma Extra-adrenal paragangliomA

What 2 molecules are implicated in systemic castelman disease?

IL-6 and VEGF

Translocation in ewing sarcoma

t(11;22) EWSR1-FLI1

What is most accurate evidence for death due to anaphylaxis

serum beta tryptase

follicular cervicitis is associated with what?

Chlamydia trachomatis

Which germ cell tumor shows increased AFP?

Yolk sac

What tumor has schiller-duvall bodies

yolk sac