TLRs Flashcards
What PAMPs/DAMPs does TLR1+ and TLR2 recognize?
PAMPs - Triacylated lipoproteins (Pam3cSK4), Peptidoglycans, Lipopolysaccharides
-Also TLR2 responds to DAMPs of TLR2+ and TLR6
What PAMPs/DAMPs does TLR2+ and TLR6 recognize?
PAMPs - Diacylated lipoproteins (FSL-1)
DAMPs - Heat shock proteins (HSP 60, 70, Gp96), High mobility group proteins (HMGB1), Proteoglycans (Version, Hyaluronic Acid Fragments)
What PAMPs and DAMPs does TLR3 recognize?
PAMPs - dsRNA (poly I:C), tRNA, siRNA
DAMPs - mRNA, tRNA
What PAMPs and DAMPs does TLR4 recognize?
PAMPs - LPS, Paclitaxel
DAMPs - Heat shock proteins (HSP22, 60, 70, 72, Gp96), High mobility group proteins (HMGB1), Proteoglycans (Version, Heparin sulfate, Hyaluronic Acid fragments), Fibronectin, Tenascin-C
What PAMPs and DAMPs does TLR5 recognize?
PAMPs - Flagellin
DAMPs - None
What PAMPs and DAMPs does TLR7 recognize?
PAMPs - ssRNA, Imidazoquinolines (R848), Guanosine analogs (Loxoribine)
DAMPs - ssRNA
What PAMPs and DAMPs does TLR8 recognize?
PAMPs - ssRNA, Imidazoquinoline (R848)
DAMPs - ssRNA
What PAMPs and DAMPs does TLR9 recognize?
PAMPs - CpG DNA, CpG ODNs
DAMPs - Chromatin IgG complex
What PAMPs and DAMPs does TLR10 recognize?
PAMPs - Profilin-Like proteins
DAMPs - NONE
What TLRs only produce Pro-Inflammatory Cytokines (TNF-alpha, IL-6, IL-12)?
TLR1+, TLR2, TLR2+, TLR6, TLR5, TLR10
What TLRs produce IFN-beta (via IRF3)?
TLR3 (dsRNA Poly I:C) and TLR4 (LPS)
What TLRs produce IFN-alpha (via IRF7)?
TLR7, TLR8 (ssRNA), TLR9 (CpG-DNA)
What transcription factor does TLR3 and TLR4 turn on?
IRF3
What transcription factor does all TLRs turn on (especially TLR4, TLR1+, TLR2, TLR2+, TLR6, TLR5)?
AP-1, p50, p65
What transcription factor does TLR7, TLR8 and TLR9 turn on?
IRF7
