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Tissues Flashcards

1
Q

Tissues

A

collections of specialized cells and their extracellular matrix (non-cellular extracellular substance surrounding them) that perform a relatively limited number of function.

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2
Q

whats the 4 tissues types

A

epithelial, connective, muscle and nervous

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3
Q

Epithelial tissues

A

• covers all surfaces and lines all hollow structures

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4
Q

Cellularity of epithelial tissues

A

composed almost entirely of cells with very little extracellular matrix and closely bound by specialized junctions

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5
Q

Polarity of epithelial tissues

A

has distinct surfaces

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6
Q

Apical surface

A

= free surface not attached to any other cells

• faces external environment (atmosphere) or internal environments such as fluid in tubes

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7
Q

• microvilli =

A

non-motile projections of the cell membrane (containing microfilaments) on most epithelia
• increase surface area for absorption and secretion
• so dense in the first portion of the kidney tubule known as the “brush border”

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8
Q

cilia

A

motile projections on the apical surface of the cells that can sweep substances such as mucus along the tube – e.g. pseudostratified ciliated columnar epithelium of the trachea

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9
Q

lateral surface

A

site of specialized attachment to neighbouring cells

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10
Q

basal surface

A

site of attachment to basal lamina

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11
Q

Basal lamina (attachment)

A

specialized type of extracellular material secreted by epithelial and connective tissue cells (Fig 3.3)
• important role in tissue repair

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12
Q

avascular (epithelial)

A

contains no blood vessels therefore relies on diffusion of gases and nutrients from blood vessels located in underlying connective tissue

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13
Q

arrangement (epithelial)

A

sheets or layers

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14
Q

regeneration (epithelial)

A

continually replaced by division of stem cells found close to basal lamina

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15
Q

Function of epithelial cells

A
  • protection of underlying structures
  • acting as a barrier – prevents certain substances from crossing, barrier to water and limits water loss from body
  • allows passage of certain substances– readily exchanges oxygen and carbon dioxide through lung epithelium and others epithelium are more selective – filtering at the kidney
  • secretion – mucus glands, sweat glands, and enzyme-secreting portions of the pancreas are all composed of epithelial cells that secrete their products onto surfaces or into ducts
  • absorbing substances – contain specialized carrier proteins on their membranes that allow specific components to be transported – e.g. intestinal epithelium
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16
Q

classification of epithelial cells

A
  • most epithelium classified by two names: the first indicates the number of layers and the second indicates the shape of the cell
  • others may have other descriptors added based on the presence of specialized features such as microvilli or cilia
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17
Q

simple epithelium

A

single layer of cells
• relatively thin and fragile
• found where secretion, absorption or filtration occurs
• provides smallest diffusion distance

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18
Q

stratified epithelium

A

more than one layer of cells

• found in areas subjected to significant mechanical or chemical stresses

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19
Q

stratified epithelium can be classified as :

A
  • nonkeratinized = moist
  • keratinized = dry, durable and moisture resistant and found in the skin where the outer most layers are composed of dead cells
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20
Q

transitional epithelium

A

unique type of stratified epithelium that lines the urinary bladder, ureters, pelvis of the kidney and superior portion of the urethra. Shape of the cells and the apparent number of layers vary with the amount of stretch on the bladder.

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21
Q

o pseudostratified (pseudo = false) columnar epithelium

A

is actually one layer of cells with all cells attached to the basement membrane but appears to be multilayered because some cells are shorter and do not extend to the free surface
• usually ciliated

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22
Q

• Shape of the Superficial Cells

A 
quamous (Fig 3.4) = flat or pancake like
o	cuboidal (Fig 3.5) = cube-shaped – as wide as they are tall
o	columnar (Fig 3.6) = tall and thin – similar to a column
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23
Q

Glandular epithelium - secretory organs

A

o primarily composed of epithelium with supporting network of connective tissue

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24
Q

exocrine glands

A

glands that contain ducts (lined with epithelium) – dump their products into ducts that empty onto external surfaces (such as the skin) or into organ lumen (such as the intestine)
o categorized by nature of secretions

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25
serous glands
watery solution usually containing enzymes
26
muscous glands
secrete glycoprotein mucin
27
• mixed exocrine glands
more than one type of cell present allows serous and mucous secretions o most are multicellular
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globlet cells
specialized unicellular mucus secreting cells | o multicellular glands classified according to
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• structure of ducts:
• tubular, or acinar (alveolar) = sac-like
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• complexity:
* simple – does not branch | * compound – branch repeatedly
31
merocrine
- no cellular material lost – e.g. sweat glands
32
apocrine
apical fragments of the cell released and gland cells regrow – e.g. mammary glands
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halocrine
entire cells with products shed, destroying cells – e.g. sebaceous (oil) glands
34
• endocrine glands
release secretions into interstitial fluid (fluid surrounding cells) ex : hormones
35
HORMONES
products diffuse into blood to be carried to target tissues
36
connective tissue
• abundant – part of every organ • 3 basic components (Fig 3.12) o specialized cells o extracellular protein fibers o fluid – known as ground substance • extracellular matrix = extracellular proteins + ground substance • cells separated from each other by lots of extracellular matrix
37
functions of connective tissues
* enclosing and separating other tissues (packing material) * connecting tissues to one another – tendons (muscle to bone), ligaments (bone to bone) * supporting and aiding in the movement of the body – bony skeletal, joints between bones * energy/nutrient storage – adipose tissue stores fat, bones store minerals * cushioning and insulating – adipose tissue protects the tissue it surrounds and the insulating layer below the skin conserves heat * transportation – blood * protection – lymph with cells of the immune system, bones
38
fixed c ells (c.T)
• fixed cells = stationary o provide local maintenance, repair and energy storage o (suffixes) blasts = “build”/ create more matrix • fibroblasts = most abundant cell in connective tissue proper • produce all connective tissue fibers o “-cytes” = normally functioning cells that “maintain” matrix • fibrocytes o clasts = “clear”/ remove extracellular matrix – osteoclasts (remove bony matrix) o adipose (fat) cells = adipocytes – large amounts of lipid stored pushes rest of cell contents to periphery
39
wandering cells
• wandering cells – number varies depending on local conditions o involved in defence and repair of damaged tissue
40
mast cells ( wandering cells)
cells in loose connective tissue. Contain chemicals such as heparin and proteolytic (breakdown proteins) enzymes that are released in response to tissue injury
41
leukocytes (wandering cells)
immune/defence cells that move from the blood into loose connective tissue and then back to the blood via the lymph system
42
macrophages
phagocytic (eat large particles and cells) – can be “fixed” (lie in wait and do not wander through the connective tissue), or “wandering” with ameboid-like motions
43
platelets
fragments of specialized cells that are released into the blood and contain enzymes and special proteins important in the clotting of blood and prevention of blood loss
44
o mesenchymal stem cells
respond to local injury or infection in connective tissue and have the potential to differentiate into multiple different cells such as macrophages and fibroblasts
45
extracellular matrix
* contains: protein fibers and ground substance | * protein fibers: (Fig 3.12)
46
collagen fibers
rope-like” collagen proteins and most abundant protein in the body • made by fibroblasts and form bundles that provide strength and resist being pulled
47
reticular fibrer
“net-like” proteins - very short, thin fibers that branch to form a network • chemically identical to collagen - just very fine fibers that fill spaces between tissues and organs
48
elastic fibers
can be stretched or compressed and returns to its original shape • ground substance – appears as shapeless background in microscope but molecules highly structured
49
hyaluronic acid
= long, un-branched polysaccharide (sugar) chain that gives slippery quality to fluid • lubricant for joint cavities, major component of vitreous humor of the eye
50
o mixture of proteoglycans and glycoproteins
protein and polysaccharides that interact to determine consistency • eg. GAGS - glycosaminoglycans such as chrondroitin sulphate
51
connective tissue proper | Loose cT
contains many types of cells and extracellular fibers in a syrupy ground substance • Loose connective tissue (Fig 3.12, 3.14) – relatively few protein fibers forming lacy network with numerous spaces filled with ground substance and fluid o areolar tissue = loose packing material of most organs and attaches skin to underlying tissues • least specialized and contains all cells found in connective tissue proper • fibroblasts, macrophages, lymphocytes and some adipocytes plus a variety of extracellular proteins • can be distorted without damage
52
adipose tissue (loose CT)
adipocytes – contain large amount of lipid • unlike other connective tissues – quite cellular with small amount of extracellular matrix • acts as insulator, protective tissue and energy storage
53
reticular tissue
contains fibroblasts that produce and secrete reticular fibers • in bone marrow and liver, forms framework of lymphatic organ - spleen and lymph nodes
54
Dense C.T
• Dense connective tissue (Fig 3.15) – fibroblasts and large number of protein fibers that form thick bundles
55
dense regular C.t
o dense regular connective tissue – fibers in extracellular matrix oriented in predominately one direction • dense regular collagenous connective tissue = fibers made of collagen – found in tendons, ligaments • elastic connective tissue = fibers are parallel bundles of collagen plus lots of elastin in walls of blood vessels and respiratory passages
56
dense irregular c.T
meshwork of fibers in random orientation, or one layer in one direction and next layer at 90o orientation • form sheets with strength in many directions but less that dense regular which has higher strength in a specific direction • dense irregular collagenous connective tissue – forms most of the dermis (inner portion of the skin), and connective tissue capsules around organs such as kidney and spleen
57
Fluid connective tissue
blood and lymph – collections of distinctive cells in a fluid matrix • Blood – contain erythrocytes (red blood cells), leukocytes (white blood cells) and platelets (cell fragments) and matrix between cells is plasma - mainly water with some proteins • Lymph = interstitial fluid and lymphocytes = 99% of cells
58
Supportive C.T
cartilage and bone – provide strong framework that supports rest of body
59
cartilage (supportive)
composed of chondrocytes (cartilage cells) located in spaces called lacunae surrounded by extensive and relatively rigid gel matrix containing chondroitin sulfates o has no blood vessels or nerves (except in the perichondrium – dense irregular connective tissue surrounding the cartilage) therefore heals very slowly after injury divided into hyaline, elastic and fibrocartilage
60
Hyaline cartilage
most common type • collagen fibers small and evenly dispersed in extracellular matrix making it look transparent • strong and has some flexibility • found in rib cage, trachea, bronchi, covers all articular (joint) surfaces of bones • forms framework for bony skeleton
61
elastic cartilage
contains large amount of elastin fibers in extracellular matrix • provides stretch and flexibility – found in pinna of ear
62
fibrocartilage
– has thicker bundles of collagen and is only slightly compressible and very tough • acts as pads and shock absorbers • found in knee (menisci), vertebral discs, pubis symphysis, temporomandibular joint
63
bone
composed of osteocytes (bone cells) within lacunae and surrounded by hard bony matrix with organic and inorganic portions o organic portion of matrix primarily collagen fibers o inorganic portion = hydroxyapatite = crystals of calcium and phosphate o has rich supply of blood - repairs well o canaliculi = passages formed by slender cytoplasmic extensions of osteocytes that communicate with other osteocytes and blood vessels
64
spongy bone
spaces between trabeculae (beams of bone) – “sponge-like” appearance • provides strength and support but is lighter than compact bone • found on inner portion and ends of long bones, vertebrae, sternum, skull and pelvis
65
compact bone
more solid with almost no space between many thin layers called lamellae • layer found on surface of all bones – thickness varies from region to region • osteon = functional unit of compact bone
66
periosteum
covers bony surfaces– fibrous outer layer and cellular inner layer

antomy (13 decks)

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