Tissue Repair and Wound Healing Flashcards
What are two broad types of tissue repair?
Regeneration
Scar formation
What is deposited in scar formation?
Collagen
What drives tissue repair?
Growth factors
What must be intact for regeneration to be possible? (Vs. scar formation)
ECM
Which cell type is most likely to be repairable? Which is least likely
Labile - most
Permanent - least
What gives ECM its compressibility?
Proteoglycans
What is defective in the ECM in Marfan Syndrome?
Elastin
How does the ECM control cell proliferation?
By binding and displaying growth factors
What are the three steps to scar formation? Which cell plays a crucial role? What is the most important cytokine involved?
Angiogenisis
Granulation tissue
Connective tissue remodeling
Macrophages - TGF-beta
What vitamin deficiency inhibits collagen synthesis?
Vitamin C
What is the difference between healing by first intention (primary union) and healing by second intention (secondary union)?
Primary - surgical incision, epithelial injury with only focal disruption to basement membrane
Secondary - large wound, combo of regeneration and scar
A surgical scar/wound has what strength in 1 week? What strength in 3 months?
10%
70-80%
What is a keloid?
Excessive collagen deposited beyond boundaries of wound
What is exuberant granulation tissue (proud flesh)? Can it heal on its own?
Granulation tissue that extends above surround skin
No, must be surgically removed
