Cellular Accumulation and Aging Flashcards
What type of intracellular accumulation is Alpha-1-antitrypsin deficiency?
Defective protein transport/folding
What stains with Old Red-O stain?
Lipids/fats
What color is a liver when lipid accumulates? What does the slide look like?
Orange/Yellow
Lots of round white spaces
Cholesterol filled histiocytes in the gallbladder manifest/are visualized as what?
Yellow Streaks
What intracellular/extracellular acuumulation appears glassy, pink, caused by “hyaline change?”
Protein accumulation
What disease are Mallory Denk bodies associated with? What particular protein accumulation are they ok?
Alcoholic liver disease
Cytoskeletal Proteins
What accululates in Amyloidosis? Where? What specific confirmation?
Proteins
Extracellular
Cross-B-pleated sheet
Acquired mutations produce what type of protein? Chronic inflammation?
AL protein
AA protein
What staining do you use for Amyloid? What color is it? How does the color change when you use polarized light?
Congo Red stain
Pink-red
Green birefringence under polarized light
What two diseases can be caused by localized amyloidosis?
Alzheimers
Type 2 diabetes
What intracellular accumulation is dark and is often seen in the lung in a certain subset of the population?
Carbon
What disease shows dark brown scattered pigment in the skin?
Malignant melanoma
When a cell is aging and turns golden brown, what is accumulating?
Lipofuscin
What is hemosiderin and accumulation of? What is used to stain it?
Iron contain hemoglobin pigment
Prussian blue stain
What is the difference between dystrophic calcification and metastatic calcification?
Dystrophic - abnormal deposit during normal serum calcium levels
Metastatic - deposit during hypercalcemia
