Tissue Mechanics Bone Flashcards
What is the intercellular calcified bone matrix composed of (3)
- Inorganic matter
- Water
- Organic matter
What percent of the intercellular matrix of bone is inorganic matter
60-70%
What is the inorganic matter of the intracellular matrix of bone
Hydroxyapatite crystals
What percent of the intercellular matrix of bone is water
5-8%
What percent of the intercellular matrix of bone is organic matter
22-35%
Where is inorganic matter embedded in
Variously oriented fibers of protein collagen (fibrous portion of extracellular matrix)
What is make up the greatest percentage of the ECM organic matter
Type I collagen
How much of the ECM organic matter does type I collagen make up
90%
How much of the dry weight of bone does type I collagen make up
25-30%
What composes the ECM organic matter of bone (4)
- Type I collagen
- GAGs
- PGs
- Glycoproteins
What do GAGs do in the ECM organic matter
Serve as cementing substance between osteons
What percent of the ECM are GAGs
About 5%
What do the glycoproteins contain in the ECM organic matter
Glutamic acid
What does glutamic acid do
Causes glycoproteins to bind to calcium
What do GAGs do for the bone
Give it the ability to absorb stress and share it across the bone
What is the main portion of the inorganic of the ICM
Calcium and phosphorus
What form do calcium and phosphorus take in the inorganic matter of the ICM
Hydroxyapatite crystals
What makes bone such a dynamic tissue
Bone cells
What are the 3 bone cells
- Osteocyte
- Osteoblast
- Osteaoclast
What are osteocytes
Mature cells
What are osteoblasts
Young cells for growth
What are osteoclasts
Phagocytic
What is constantly going on in existing bone hopefully inbalance
Bone tissue deposition and bone tissue resorption
What happens more during growth
Deposition
What happens more during aging
Resorption
What happens more during healing
Hopefully both are equal
What happens more during exercise
Resorption
What occurs when bone deposition decreases
Disuse atrophy
Following 8 weeks of immobilization what can happen to load to failure, stiffness, and energy storing capacity
A 3 fold decrease