Thyroid Gland Pathology Flashcards
which thyroid gland is more rostral/cranial
right thyroid
what color is colloid on histology
pink - colloid is proteinaceous due to thyroglobulin
relative thyroid hormone form abundance
protein bound T4 > protein bound T3 > free T4 > free T3
thyroid follicular cysts
multifocal cysts that cause bilateral thyroid enlargement
species: goats
NOT associated with endocrinopathy
what species is thyroid hypofunction most commonly seen in
dogs and horses
causes of hypothyroidism
- lymphocytic thyroiditis
- idiopathic follicular atrophy
- goiter
- congenital thyroid gland hypofunction
lymphocytic thyroiditis
immune mediated atrophy of the thyroid gland
bilateral thyroid atrophy with lymphocytic infiltrate
possibly predisposes to idiopathic follicular atrophy
idiopathic follicular atrophy
loss of thyroid glandular tissue - replaced by connective tissue
possible sequelae to lymphocytic thyroiditis
bilateral thyroid atrophy
goiter
congenital thyroid gland hyperplasia
something interferes with T3/4 synthesis in utero leading to overstimulation of TRH and TSH –> follicular hypertrophy without increasing T3/4 production –> hypothyroid with enlarged thyroid glands
bilateral thyroid enlargement
what are possible causes of goiter
- iodine deficiency of the dam
- genetic defects (lack of TP enzyme)
- dam consumption of goitrogenic substances
- high iodine ingestion (unknown mechanism)
congenital thyroid gland hypofunction
similar to goiter but does NOT cause the same lesion
- hypothyroidism without thyroid gland enlargement
- stunted growth, delayed tooth eruption, delayed secondary ossification
seen in carnivores and horses
thyroid hyperfunction
disorders of growth of the thyroid
hyperplasia –> adenoma –> carcinoma
what species is hyperthyroidism common in
cats: functional hyperplasia
horses: adenomas (nonfunctional)
dogs: carcinomas (nonfunctional)
thyroid adenoma/nodular hyperplasia
multiple nodules on the thyroid glands that secrete excess T3/4
seen in cats most commonly
difficult to differentiate between nodular hyperplasia and adenomas (unilateral more likely adenoma)
secondary lesions associated with hyperthyroidism in cats
- left ventricular concentric hypertrophy
- hyperactivity
- azotemia
- weight loss + polyphagia
- vomiting
- hyperparathyroidism