Thyroid Gland Pathology Flashcards

1
Q

which thyroid gland is more rostral/cranial

A

right thyroid

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2
Q

what color is colloid on histology

A

pink - colloid is proteinaceous due to thyroglobulin

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3
Q

relative thyroid hormone form abundance

A

protein bound T4 > protein bound T3 > free T4 > free T3

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4
Q

thyroid follicular cysts

A

multifocal cysts that cause bilateral thyroid enlargement

species: goats

NOT associated with endocrinopathy

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5
Q

what species is thyroid hypofunction most commonly seen in

A

dogs and horses

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6
Q

causes of hypothyroidism

A
  1. lymphocytic thyroiditis
  2. idiopathic follicular atrophy
  3. goiter
  4. congenital thyroid gland hypofunction
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7
Q

lymphocytic thyroiditis

A

immune mediated atrophy of the thyroid gland

bilateral thyroid atrophy with lymphocytic infiltrate

possibly predisposes to idiopathic follicular atrophy

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8
Q

idiopathic follicular atrophy

A

loss of thyroid glandular tissue - replaced by connective tissue

possible sequelae to lymphocytic thyroiditis

bilateral thyroid atrophy

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9
Q

goiter

A

congenital thyroid gland hyperplasia

something interferes with T3/4 synthesis in utero leading to overstimulation of TRH and TSH –> follicular hypertrophy without increasing T3/4 production –> hypothyroid with enlarged thyroid glands

bilateral thyroid enlargement

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10
Q

what are possible causes of goiter

A
  1. iodine deficiency of the dam
  2. genetic defects (lack of TP enzyme)
  3. dam consumption of goitrogenic substances
  4. high iodine ingestion (unknown mechanism)
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11
Q

congenital thyroid gland hypofunction

A

similar to goiter but does NOT cause the same lesion
- hypothyroidism without thyroid gland enlargement
- stunted growth, delayed tooth eruption, delayed secondary ossification

seen in carnivores and horses

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12
Q

thyroid hyperfunction

A

disorders of growth of the thyroid

hyperplasia –> adenoma –> carcinoma

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13
Q

what species is hyperthyroidism common in

A

cats: functional hyperplasia
horses: adenomas (nonfunctional)
dogs: carcinomas (nonfunctional)

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14
Q

thyroid adenoma/nodular hyperplasia

A

multiple nodules on the thyroid glands that secrete excess T3/4

seen in cats most commonly

difficult to differentiate between nodular hyperplasia and adenomas (unilateral more likely adenoma)

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15
Q

secondary lesions associated with hyperthyroidism in cats

A
  • left ventricular concentric hypertrophy
  • hyperactivity
  • azotemia
  • weight loss + polyphagia
  • vomiting
  • hyperparathyroidism
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16
Q

thyroid carcinoma

A

large, locally invasive masses that do NOT secrete excess T3/4 (non functional)

more common in dogs

can invade internal carotid and vagosympathetic trunk