Thyroid Drugs (FA) Flashcards
1
Q
What are the drugs used in hyperthyroidism?
A
Methimazole, Propylthiouracil (PTU)
2
Q
What is the common MoA of hyperthyroid drugs? What is unique about PTU?
A
Both block thyroid peroxidase, blocking oxidation and coupling of iodine
PTU also works on 5’-deiodinase, blocking peripheral T4 –> T3
3
Q
What side toxicity is unique to PTU?
A
Hepatotoxicity
4
Q
What hyperthyroid drug is used in pregnancy?
A
PTU in the first trimester
5
Q
What drugs are used in hypothyroidism and their mechanism?
A
Levothyroxine, Triiodothyronine
Thyroxine replacement
6
Q
What are the toxicities of hypothyroid drugs?
A
Induced hyperthyroidism: tachy, heat intolerance, tremors, arrhythmias
