Endo Path - Misc. (FA) Flashcards
What is the cause of carcinoid syndrome?
Carcinoid tumor secretes 5-HT
What is the most common cancer that causes carcinoid syndrome?
Metastatic Sm. Bowel tumors
What are the common symptoms of a carcinoid tumor?
Recurrent diarrhea, flushing, asthmatic wheezing, right sided valvular disease
Increased 5-hyproxyindoleacetic acid (5-HIAA) in urine and niacin deficiency?
Carcinoid tumor
What is the cause of Zollinger-Ellison syndrome?
Gastrin secreting tumor of pancreas or duodenum
Second most common cause of PUD?
ZE syndrome
What are the three Ps of MEN1?
Pituitary
Parathyroid
Pancreas
Think of the diamond
What are the conditions of MEN2A?
Medullary thyroid
Parathyroid
Pheo
Think of the square
What are the conditions of MEN2B?
Medullary thyroid
Mucosal
Pheo
Think of the triangle
Which form of MEN is associated with marfanoid habitus?
MEN 2B
What are the most common hormones secreted in MEN 1?
Prolactin, GH, Insulin, Gastrin, VIP (GI issues)
What is secreted by a medullary thyroid carcinoma and its effects?
Calcitonin: reduces bone reabsorption –> low Ca++
What is the inheritance pattern of MEN?
AD
What gene is associated with MEN 2A and 2B?
RET