Thyroid Drugs [13] Flashcards
Thyroid hormones fall into steroid category but …
They aren’t derived from cortisol
They are derived from amino acids
What is the thyroid gland for
Brain development
Bone maintenance
Metabolic control
What is in the colloid
Thyroglobulin - precursor to thyroid hormone production
T3 & T4 =
Thyroglobulin + iodide
How is T3/4 released in the body
Hypothalamus released TRH
Pituitary releases TSH
Thyroid released T3/4
What are the names of T1, T2, T3 and T4
Monoiodotyrosine
Diiodotyrosine
Triiodothyronine
Thyroxine
What enzyme allows iodisation of tyrosine to make T1/2
Thyroperoxidase (TPO)
How are are T3/4 synthesised
Tyrosine residues on thyroglobulin
Iodide from bloodstream
Both move into colloid
Iodination & coupling
T1 + T2 = T3
T2 + T2 = T4
4 thyroid receptors?
TR alpha 1&2
TR beta 1&2
When on receptors do T3 & 4 bind
Ligand binding domain
What does hinge region on receptor do
Orientates DNA binding
Protects DBD
Makes sure LBD isn’t in the way of other txn factors
Treatments for hypothyroidism
Synthetic thyroid hormones
Synthetic T4 - levothyroxine
Synthetic T3 - liothyronine sodium
What is Hashimoto’s disease
Hypothyroidism
Destruction of follicular cells
What’s carcinoma
Hypothyroidism
Cells don’t function as they should
symptoms of hyperthyroidism
High metabolic rate
Sweating
Tremor
Tachycardia
