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PED2006 - Systems Pharmacology > GI System Secretion [1] > Flashcards

GI System Secretion [1] Flashcards

1
Q

Function of GI (4)

A

Metabolism
Gastric secretion
Vomiting
Bowel motility

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2
Q

Two types of hormone are where are they found

A

Endocrine (bloodstream)
Paracrine (blood)

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3
Q

Example of endocrine hormone

A

Gastrin

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4
Q

Eg of paracrine hormone

A

Histamine
Ach

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5
Q

Parietal cells. Where and what?

A

Walls of gastric gland
Make gastric acid

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6
Q

Intercellular process that histamine binding in parietal cell affects?

A

Stimulates proton pump
More K+ in and more H+ out in lumen

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7
Q

How is HCl made in lumen

A

Cl- is constantly loss - electrochemical gradient
H+ out of proton pump

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8
Q

Cell 1 hypothesis

A

Mast cells makes more histamine - more proton pump stimulation

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9
Q

Cell 2 hypothesis

A

Ach and gastric stimulate mast cell to make more histamine

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10
Q

Two hormones that increase cytosolic ca2+

A

Gastrin and histamine

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11
Q

Hormone that increase cytosolic camp

A

Histamine

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12
Q

Acid disregulation dispepsia is also known as

A

Indigestion

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13
Q

Acid disregulation diseases (4)

A

Dyspepsia
Peptic ulcers
Reflux oesophagitis
Zollinger-Ellison syndrome

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14
Q

3 therapies for acid disregulation

A

Proton pump inhibitors
H2 antagonists
Antacids

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15
Q

Eg of PPI

A

Omeprazole or Iansoprazole

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16
Q

PPIs are stable at low pH true or false

A

False - degrade rapidly at low pH so have enteric coating which is removed in alkaline duodenum

17
Q

Eg of H2 antagonists

A

Cimetidine or ranitidine

18
Q

Commoner adverse effect of H2 antagonists

A

Inhibition of CYP450s so other drugs can’t be metabolised

19
Q

Eg of antacid

A

Sodium bicarbonate

20
Q

Add verse effect of antacid

A

Acid rebound
Rise in pH causes gastric emptying so stomach fills back up with acid

21
Q

What is the triple therapy of heliobacter pylori infections

A

PPI
Antibacterials
Cytoprotective agents

22
Q

Eg of cytoprotective agent and how does it work

A

Misoprostol
- prostaglandin analogue
- prostaglandins increase mucus & bicarbonate secretion
- decrease acid secretion

PED2006 - Systems Pharmacology (19 decks)

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