Endocrine Signalling & Pituitary [12] Flashcards
Where do hormones come from
Endocrine tissue
Examples of endocrine glands
Pituitary
Hypothalamus
Pancreas
Ovaries
Testes
Thymus
Thyroid
What is a steroidal hormone
Can pass through membrane & bind Intracellularly
Receptor of txn factor
Non-steroidal hormone definition
Binds to membrane bc it can’t pass through
Sets off signalling cascade
What controls the pituitary
The hypothalamus
What does the posterior lobe of the the pituitary do
Stores secreted hormones made by hypothalamus
(ADH)
What does the anterior lobe of the pituitary do
Synthesises & secretes hormones in response to hypothalamic regulation (GH)
In the PP, axons extend from the …
Supraoptic & paracentricular nuclei of hypothalamus
In the PP, axons release …
Peptide hormones into hypophyseal circulation
In the PP, hormones are stored in …
Neurosecretory vesicles
Explain the action of ADH
Binds V2 receptors on basolateral of principal cells
Promotes ATP —> camp by adenylate cyclase
Activates PKA
Fusion of aquaporins into luminal membrane
Enhances permeability to water in CD
Concentrated urine
ADH level stimulants
MDMA
Opioids
ADH level depressants
Alcohol
What is SIADH
Syndrome of inappropriate ADH secretion
Excessive ADH
Increased body water
Hyponatremia
Causes of SIADH
Head trauma
Tumours
