Thyroid and Parathyroid Agent

Question 1

levothyroxine classification:

Answer 1

thyroid replacement drug

Question 2

levothyroxine mech of action:

Answer 2

thyroid preparations are given to replace what the thyroid gland cannot produce to achieve normal thyroid levels

Question 3

levothyroxine indication:

Answer 3

replace what the thyroid gland itself cannot produce to achieve euthyroid condition

Question 4

levothyroxine contraindications:

Answer 4

allergy, MI, adrenal insufficiency, hyperthyroidism

Question 5

levothyroxine adv effects:

Answer 5

insomnia, tremors, tachycardia, HTN, menstrual irregularities, weight loss, sweating, heat intolerance

Question 6

What is levothyroxine used for?

Answer 6

HYPOthyroidism

Question 7

levothyroxine interactions:

Answer 7

phenytoin and fosphenytoin reduces effectiveness, increase warfarin effects, antacids, calcium, iron, estrogen reduces effects

Question 8

Propylthiouracil classification:

Answer 8

anti-thyroid drug

Question 9

Propylthiouracil mech of action:

Answer 9

inhibits the incorporation of iodine molecules into the amino acid tyrosine, required to make the precursors of T3 and T4

Question 10

Propylthiouracil indications:

Answer 10

HYPERthyroidism, prevent surge in thyroid hormone after surgical treatment or during radioactive iodine therapy

Question 11

Propylthiouracil contraindications:

Answer 11

allergy

Question 12

Propylthiouracil interactions:

Answer 12

bone marrow suppressants, anticoagulants

Question 13

Propylthiouracil adv effects:

Answer 13

drowsiness, vertigo, enlarged thyroid gland, loss of taste, bleeding, increased BUN and creatinine levels

Question 14

Propylthiouracil special considerations:

Answer 14

better tolerated when given with food, never stop abruptly, same time every day, avoid iodine/seafood, takes two weeks for symptoms to improve