Thyroid

Question 1

Spindle cell tumours

Answer 1

Hyalinising trabecular tumour

Medullary ca

PTC with modular fasciitis like stroma

PTC cribriform modular variant

Follicular ca with spindle cells

Anaplastic ca

SETTLE

Question 2

Answer 2

Hyalinising trabecular tumour

Question 3

Benign mimics of malignancy

Answer 3

FNA artefact

I 131 therapy (nuclear abnormalities)

Graves’ disease (papillary folds)

Amyloid goitre

Question 4

Granulomas

Answer 4

de Qeurvains

Sarcoidosis

Palpation thyroiditis

Infection

Question 5

Clear cell tumours

Answer 5

Hurtle cell tumour

Follicular adenoma/carcinoma

PTC

Medullary ca

Parathyroid ad/ca

RCC

Non-neo eg Hashimoto’s

Question 6

Sclerosing lesions

Answer 6

PTC diffuse sclerosing variant

Fibrosing variant of Hashimoto’s

Riedel thyroiditis/IgG4 disease

Radiation

Question 7

Malignant mimics of benign

Answer 7

PTC diffuse sclerosing variant

Paucicellular anaplastic ca

(both mimic Riedels and fibrosing Hashimoto’s)

Question 8

Hashimoto’s vs lymphoma

Answer 8

lymphoma:

dense lymphoid infiltrate

broad bands of centrocyte-like or monocytoid B cells

prominent lymphoepithelioid lesions

diffuse CD20

CD43 in B cells

light chain restriction