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Anatomical Pathology RCPA Part 2 > Lymph nodes > Flashcards

Lymph nodes Flashcards

1
Q

benign mimics of malignancy (7)

A

benign inclusions

Kikuchi lymphadenitis

EBV

Castleman disease

PTGC

extramedullary haemoatopoiesis

vascular transformation of LN sinuses

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2
Q

malignant mimics of benign

A

subtle metastases

CLL

intravascular DLBCL

paracortical pattern lymphomas: Hodgkins, ALCL

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3
Q

granulomas with necrosis

A

fungi

mycobacteria

lymphoma

yersinia

bartonella

LGV

tularemia

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4
Q

granulomas without necrosis

A

Crohn’s

sarcoid

chronic granulomatous diseases of childhood

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5
Q

necrosis without granulomas

A

infection (incl HSV/CMV)

lymphoma

Kikuchi

Kawasaki disease

SLE

HHV6

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6
Q

Kikuchi vs SLE

A

usually need clinical and serology

SLE: plasma cells++, follicular hyperplasia

Kikuchi: necrosis with debris, no follicular hyperplasia

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7
Q

eosinophils in a LN (7)

A

Kimura disease

epithelioid haemangioma

LCH

lymphomas (esp Hodgkin and T cell)

parasites

extramedullary haematopoiesis

myeloid sarcoma

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8
Q

plasma cell in a LN

A

CIRRIS

Castlemans (PC type)

IgG4 disease

Rosai-Dorfman

rheumatoid arthritis

chronic infection

SLE

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9
Q

partial effacement, small granulomas

A

toxoplasmosis

syphilis

EBV

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10
Q

histiocytes in a LN

A

dermatopathic lymphadenopathy

LCH

Rosai-Dorfman

haemophagocytic lymphohistiocytosis

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11
Q

spindle cells in a LN

A

Kaposi sarcoma

vascular transformation of sinuses

inflammatory pseudotumour (CD68+, ALK-)

mycobacterial spindle cell pseudotumour

palisaded myofibroblastoma (look like schwannoma with haemorrhage and amianthoid fibres)

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12
Q

clear cells

A

marginal zone lymphoma

T cell lymphomas

mastocytoma

hairy cell leukaemia

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13
Q

lymphadenopathy in HIV

A

HIV lymphoadenopathy

infections

Castlemans

Kaposi sarcoma

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14
Q

common mets in a neck node

A

NPC

PTC

medullary thyroid ca

mucoepidermoid ca

SCC

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15
Q

common mets in axillary node

A

breast (duct and lobular)

Merkel cell ca

melanoma

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16
Q

diffuse paracortical hyperplasia pattern

A

EBV, HSV, CMV

post vaccine

phenytoin

Hodgkin lymphoma

ALCL

DLBCL

17
Q

medium sized follicles

A

reactive follicular hyperplasia

follicular lymphoma

nodular mantle cell lymphoma

marginal zone lymphoma with follicular colonisation

Castleman

follicular T cell lymphoma

18
Q

Kaposi vs vascular transformation of sinuses

A

Kaposi: invades parenchyma, well formed fascicles, HHV8+

VTS: maturation toward subcapsular sinus

19
Q

reactive follicular hyperplasia vs follicular lymphoma

A

RFH: discrete follicles, well defined mantles, polarised follicles with TBMs, BCL2- follicles

20
Q

diffuse small cell lymphomas

A

CLL/SLL (proliferation centres)

mantle cell

marginal zone

lymphoplasmacytic

diffuse follicular

21
Q

large lymphoid nodules

A

NLPHL

cHL (nodular sclerosis and lymphocytes rich subtypes)

PTGC (diffuse CD20+ follicle, no CD3 rosetting)

follicular lymphoma

22
Q

scattered large cells with small cell background

A

classical Hodgkins

NLPHL with diffuse growth pattern

T cell rich LBCL

reactive lymphoid hyperplasia

peripheral T cell lymphoma NOS

23
Q

diffuse large cell proliferation

A

DLBCL

ALCL

cHL with large cell predominance

peripheral T and NK/T cell lymphoma

24
Q

diffuse medium sized proliferation

A

Burkitt

lymphoplasmacytic

blastoid mantle

myeloid sarcoma

DLBCL

25
Q

starry sky

A

Burkitts

lymphoblastic lymphoma

myeloid sarcoma

DLBCL

blastic mantle

normal germinal centre!

Anatomical Pathology RCPA Part 2 (30 decks)

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