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Anatomical Pathology RCPA Part 2 > Kidney > Flashcards

Kidney Flashcards

1
Q

benign mimics of malignancy

A

xanthogranulomatous pyelonephritis

malakoplakia

metanephric adenoma

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2
Q

malignant mimics of benign

A

sarcomatoid carcinoma with granulomatous inflammation

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3
Q

multicystic kidneys

A

cystic renal dysplasia

PKD infantile

PKD adult

medullary sponge kidney

medullary cystic kidney disease

acquired renal cystic disease

nephronophthisis

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4
Q

cystic lesions

A

simple cyst (no clear cells)

cystic nephroma/MEST (ovarian type stroma, no clear cells)

multilocular cystic renal neoplasm of low malignant potential (new name) (circumscribed, clear cells in septa)

RCC with cystic degeneration (expansile nodules of clear cells)

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5
Q

cystic lesions in kids

A

cystic nephroma/MEST (mature epithelium and stroma)

cystic partially differentiated nephroblastoma (immature stroma)

Wilms’ tumour with cystic areas

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6
Q

clear cell/papillary tumours

A

clear cell RCC (CD10+)

papillary RCC (CK7 diffuse)

Xp11 translocation RCC (CK7+, CD10+, TFE3+)

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7
Q

oncocytic lesions

A

oncocytoma (CD117+/-, CK7 focal)

chromophobe ca (CD117+, cytoplasmic CK7)

AML (HMB45+)

clear cell RCC (CD117-, CD10+)

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8
Q

undifferentiated epithelioid lesions

A

RCC

PEComa

adrenal cortical ca

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9
Q

epithelioid/spindled tumours around vessels

A

PEComa

juxtaglomerular cell tumour (SMA+, CD31+)

glomus tumour

carcinoid

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10
Q

tubulopapillary lesions

A

metanephric adenoma

papillary RCC

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11
Q

spindle cell lesions

A

AML
IMT
sarcomatoid ca

urothelial ca

leiomyosarcoma

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12
Q

high grade tumours

A

papillary RCC

collecting duct ca

urothelial ca

metastatic ca

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13
Q
A

Collecting duct carcinoma (jagged branching lumens, abundant stroma)

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14
Q

paediatric renal tumours

A

Wilms’ tumour

clear cell sarcoma

rhabdoid tumour (INI1/SMARCB1-)

mesoblastic nephroma (spindle cells with benign entrapped tubules/glomeruli)

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15
Q

renal cortical tumours

A

clear cell RCC: vim+ cd10 diffuse +

papillary RCC: vim+ ck7 diffuse +

chromophobe RCC: vim- cd117+

oncocytoma: vim- cd117+/-

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16
Q

chromophobe RCC vs oncocytoma

A

C-RCC: prominent cell borders, wrinkled nuclei, perinuc haloes, binucleation

onc: no necrosis, no halo, nested, nucleoli more common, central scar in 30%

17
Q

clear cell lesions

A

clear cell RCC

papillary RCC with clear cells

AML

xanthogranulomatous pyelonephritis

18
Q
A

metanephric adenoma:

may present with polycythaemia

uniform acini +/- papillae

psammoma bodies, degeneration/haemorrhage

wt1+

‘adenofibroma’ has spindle cell stroma

19
Q
A

Mucinous tubular and spindle cell carcinoma (low grade and spindled)

Anatomical Pathology RCPA Part 2 (30 decks)

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