Mediastinum Flashcards
Benign mimics of malignancy
thymic hyperplasia (vs type B1 thymoma)
thymic epithelial hyperplasia in thymic cysts
Malignant mimics of benign
cystic seminoma
cystic thymoma
granulomatous inflammation in malignancy
granulomas
infections
sarcoid
malignancy: Hodgkins, seminoma
anterior cysts
thymic cyst
parathyroid cyst
cystic thymoma
cystic teratoma
cystic seminoma
middle mediastinal cysts
bronchogenic cyst
pericardial cyst
posterior cysts
enterogenous cyst
lymphatic malformation
meningocele
reactive and inflammatory lesions
thymic lymphoid hyperplasia
Castleman disease
idiopathic mediastinal fibrosis (some are IgG4 related)
sarcoid
TB
spindle cell lesions
epithelial:
thymoma (type A, metaplastic)
thymic carcinoma (sarcomatoid, carcinosarcoma)
carcinoid
mesenchymal:
SFT
fibromatosis
IMT
leiomyoma/LMS
synovial sarcoma
neural tumours
other:
mesothelioma
undifferentiated large cell tumours
carcinoma: thymic, NE, parathyroid, bronchial
lymphoma: mediastinal LBL, Hodgkins
mesenchymal: paraganglioma, LMS
germ cell
mesothelioma
melanoma
undifferentiated small cell tumours
carcinoma: basaloid SCC, small cell ca
lymphoma: T-LL, Burkitt, MALT
sarcoma: Ewing, RMS, neuroblastoma
mixed small and large cell tumours
LE-like carcinoma (EBV+)
Hodgkins
primary mediastinal LBL (sclerosis, clear cells, looks like seminoma)
thymic lymphoid hyperplasia vs B1 thymoma
thymoma:
effaced architecture
jigsaw puzzle lobulation
perivascular spaces
B1 thymoma vs T-LBL
thymoma: CK and p63+ epithelial component
thymic carcinoma - DDX
metastatic carcinoma
thymoma
large cell lymphoma
metaplastic thymoma
germ cell tumour
thymic carcinoma - IPX
CD5+, CD117+
