Breast Flashcards

1
Q

benign mimics of tubular carcinoma

A

sclerosing lesions (radial scar, sclerosing adenosis, sclerosed papilloma)

microglandular adenosis

syringomatous adenoma

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2
Q

benign mimics of malignancy (5)

A

FNA/biopsy artefact

stromal giant cells (normal in fibroadenoma and benign phyllodes)

collagenous spherulosis

radiation/chemo

nevus cells in lymph node

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3
Q

Pagets vs toker cells

A

toker cells (bland, Her2-)

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4
Q

malignant mimics of benign

A

lobular ca (vs inflammation)

tubular ca (vs sclerosing lesions, MGA and syringomatous adenoma)

spindle cell carcinoma (vs benign/low grade spindled lesions)

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5
Q

granulomas

A

granulomatous mastitis

infection

foreign body (silicon/surgery)

fat necrosis

sarcoid

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6
Q

UDH vs ADH/DCIS

A

UDH mosaic CK5/6 and ER

ADH/DCIS CK5/6-, ER+

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7
Q

Pagets vs melanoma vs scc in situ

A

paget LMWCK+

melanoma melanA+

SCC HMWCK+

Sebaceous ca BerEP4+

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8
Q

cribriform lesions

A

collagenous spherulosis

cribriform DCIS

cribriform ca

adenoid cystic carcinoma

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9
Q

common low grade spindled lesions

A

metaplastic ca

phyllodes

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10
Q

rare low grade spindled lesions

A

spindle cell neuroendocrine ca

cellular PASH

myofibroblastoma

myoepithelioma

nodular fasciitis

fibromatosis

schwannoma

leiomyoma

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11
Q

high grade spindled lesions

A

spindle cell ca (subtype of metaplastic ca)

malignant phyllodes

angiosarcoma

other radiation induced sarcoma

primary breast sarcoma

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12
Q

biphasic lesions

A

fibroadenoma

phyllodes

metaplastic ca

pleomorphic adenoma

adenomyoepithelioma

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13
Q

papillary lesions

A

papilloma

papilloma with DCIS

papillary DCIS

encapsulated papillary ca

solid papillary ca

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14
Q

vascular lesions

A

PASH

perilobular hemangioma

hemangioma

atypical vascular lesion

angiosarcoma

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15
Q

atypical vascular lesion (criteria)

A

<2cm, confined to dermis, well circumscribed, no HG nuclear atypia, no mitoses, no endothelial layering

nb: post radiation angiosarcoma c-myc+ (avl is c-myc-)

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16
Q

adenomas of breast

A

tubular adenoma

lactating adenoma

ductal adenoma

nipple adenoma

fibroadenoma

pleomorphic adenoma

syringomatous adenoma

17
Q

fibroadenoma vs phyllodes

A

phyllodes older patient, more cellular, leaf-like

18
Q

benign vs malignant phyllodes

A

atypia, mitoses, infiltrative border, stromal overgrowth (>1HPF)

19
Q

complex fibroadenoma (criteria)

A

any of sclerosing adenosis, cysts >3mm, papillary apocrine hyperplasia

20
Q

plasma cells in spindled lesion - think of…

A

IMT

IgG4 disease

21
Q

malignant cartilage

A

malignant phyllodes

metaplastic ca

post radiation sarc

metastatic chrondrosarcoma

22
Q

solid papillary ca vs UDH

A

SPC: uniform cells, polarisation around cores, mucin, CK5/6-

23
Q

types of invasive lobular ca

A

classical

alveolar

solid

tubulolobular

pleomorphic