Thursday - Krafts - multiple myeloma Flashcards

1
Q

multiple myeloma things you must know

A

monoclonal plasma cell proliferation
monoclonal gammopathy
decreased normal immunoglobulins
osteolytic lesions - look real bad on x ray - leads to hypercalcemia

M spike

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

types of immunoglobulins over produced in MM

A

IgG in 60% of cases
IgA in 20% of cases
IgD or IgE in rare cases
Never IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

blood finding of MM

marrow findings

A

Blood: anemia, rouleaux, “flame cells” “russell bodies” “dutcher bodies” “Mott cells”
Marrow: plasma cells, amyloid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Waldenstrom macroglobulinemia

A

B cells
Lymphoplasmacytoid lymphoma
IgM
Hyperviscosity syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MM SSx

A

bone pain - 80%

bruizing or bleeding from decreased platelets

infections from decreased levels of normal Igs

^ Ca

Triad - anemia, bone pain , renal failure*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Biphosphonates

A

inhibit bone resorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly