Thursday - Krafts - multiple myeloma Flashcards
multiple myeloma things you must know
monoclonal plasma cell proliferation
monoclonal gammopathy
decreased normal immunoglobulins
osteolytic lesions - look real bad on x ray - leads to hypercalcemia
M spike
types of immunoglobulins over produced in MM
IgG in 60% of cases
IgA in 20% of cases
IgD or IgE in rare cases
Never IgM
blood finding of MM
marrow findings
Blood: anemia, rouleaux, “flame cells” “russell bodies” “dutcher bodies” “Mott cells”
Marrow: plasma cells, amyloid
Waldenstrom macroglobulinemia
B cells
Lymphoplasmacytoid lymphoma
IgM
Hyperviscosity syndrome
MM SSx
bone pain - 80%
bruizing or bleeding from decreased platelets
infections from decreased levels of normal Igs
^ Ca
Triad - anemia, bone pain , renal failure*
Biphosphonates
inhibit bone resorption