Friday - krafts 2 - non hodgkin lymphoma Flashcards
lymphoma - what usually brings people in
lymphadenopathy
Interfollicular hyperplasia things to know
expanded area between follicles
mixture of cells
partial effacement - only see follicles some places -
have a nice mantle zone, where follicular lymphoma doesn’t
follicular hyperplasia is a b cell response
Interfollicular hyperplasia know
expanded area between follicles
mixture of cells
partial effacement - only see follicles some places - have a nice mantle zone, where follicular lymphoma doesn’t
T cell response to some immune stimulus
follicular hyperplasia is a b cell response
when do you see tingible body macrophages
in the center of benign lymphnode follicles, but not in the center of lymphoma nodules
NHL Sx
B Sx
lymphadenopathy usually is what brings them in.
in lymphoma, lymph nodes will be more firm than in infection (but not as firm as metastatic carcinoma), it is also NOT painful!
B Sx- weight loss, night sweats, fever. these are bad prognostic things
low vs high grade NHL
low - older, indolent (incurable), small mature cells, non-destructive
high - any age, aggressive (curable?), big ugly cells, destructive
low vs high grade NHL
low - older, indolent (incurable), small mature cells, non-destructive
high - any age, aggressive (curable?), big ugly cells, destructive
small lymphocytic lymphoma things to know
same thing as CLL
small mature lymphocytes
b cells, but CD5+ weird!!
richter’s transformation
bad
lymphocytes get huge
malt lymphoma
cells come from the marginal zone
mucosal associated lymphoid tissue - can show up as a lump on endoscopy
associated with helobacter pilori - wow!
marginal zone lymphoma
actually a bunch of lymphomas
marginal zone patter
malt lymphoma
associated with helobacter pilori - wow!
where do you see marginal zones in a healthy patient
in the spleen
mantle cell lymphoma
translocation at 11;14(14 contains heavy chain genes) - bcl-1 is upregulated (this is the same as cyclin D1)
mantle zone pattern
small angulated lymphocytes
more agressive
follicular lymphoma
cells come from follicules in germinal center
small cleaved cell, mixed or large
grade 1 - good prognosis 2or 3 - bad
the better ones look more bland
BUTT CELLS!
cells are next to trabeculae
staints positive for CD20 (b cell marker)
Mycosis fungoides
skin lesions - it looks like of like eczema at first, then they kind of look like mushrooms
blood involvement
cerebriform lymphocytes! - nuclei look like brains
t cell immunophenotype
