Monday 3 - Nikcevich - Chronic Lymphocytic Leukemia Flashcards

1
Q

commonality, common age, survival

A

Most common leukemia in adults
Median age diagnosis 65 years
Median survival 9 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

absolute lymphocyte count in CLL

A

> 5000

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

flow cytometry markers in CLL

A

CD5+CD19+CD20+CD23+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

flow cytometry markers in Mantle cell lymphoma (nasty NHL) that differ from CLL

A

CD23- cyclinD1+ are the differences

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Autoimmune Complications of CLL

A
AIHA autoimmune hemolytic anemia
Coombs’ positive
Pure red cell aplasia
ITP (idiopathic thrombocytopenic purpura)
Neutropenia
^ retics
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

If you see red cell aplasia in someone without CLL, what are you thinking?

A

parvovirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What one lab test do you always get with CLL

A

FISH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

CD38 - mutated and unmutated prognosis in CLL

A

unmutated (positive) - poor prognosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ZAP-70+

good or bad in CLL

A

bad

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what do you give for CLL that makes some one have “AIDS”

what do you give to help

A

Pentodtatin - depletes CD4 T-cells well below 200.

Tx: dapsone, acyclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Smudge cells

A

in patients with 13q- CLL

good prognostic factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what do prolymphocytes look like?

A

larger that lymphocytes, a little more cytoplast (robins egg blue cytoplasm)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

cytogenetics of secondary prolymphocytic leukemia

A

richter’s transformation

new 17p-

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is really expensive but works really well for CLL

A

Ibrutinib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly