Friday last - lymphoma cases

Question 1

B Sx of lymphoma

Answer 1

> 10% weight loss

drenching night sweats

fever >38.5

Question 2

what type of cells are malignant in hodgkins

Answer 2

b cells

some are CD20

Question 3

“A” Sx of lymphoma

Answer 3

fatigue
pain with EtOH
Sx of cytopenias, anemia
Hepatosplenomegaly

Question 4

age group of HL

Answer 4

young peps and older people, but 1/5 young peps with cancer have HL

Question 5

best Tx for hodgkin lymphoma

Answer 5

ABVD X2: adriamycin (doxorubicin), bleomycin - lung tox, vinblastine - numb fingers and toes, dacarbazine

then radiate the area and done

Question 6

newest Tx for hodgkins

Answer 6

retuximab

antibody with chemo bomb

Question 7

HL thats on boards

Answer 7

nodular sclerosing classical lymphoma

Question 8

staging of lymphoma

Answer 8

1 - single LN region
2 - one side
3 - both sides of diaphram (upper and lower body)
4 - disseminated - non lymphnodes now

Question 9

What cell makers do you usually see with nodular sclerosing classical lymphoma?

Answer 9

CD15, CD30

Question 10

What do you think if you see t(14;18)

Answer 10

follicular lymphoma (non-hodgkins)

14 is immunoglobulin 14 chain

squish the 14 together to get an H, thats where IgH (immunoglobulin heavy locus) is

18 is the bcl-2 (gets its name from b cell lymphoma) - bcl-2 is anti-apoptotic and is constitutively expressed.