Thrush- Transplantation Flashcards
what type of transplant is usually autologous?
skin
what does allograft mean?
tissue transferred between genetically distinct individuals of the same species
what is graft rejection due too?
specificity and memory
what type of rejection mimics a primary immune response? and what type mimics a memory response?
first rejection.
second rejection.
which anti-T cell can allow a skin graft survive a a few more days before being rejected?
anti-CD4 (combination of both anti-CD4 and anti CD8 can postpone rejection even longer)
in a transplant do the dendritic cells of the graft serve as a antigen presenting cell (APC)?
yes
in the effector stage of graft rejection, what mediates cytotoxicity via alloantigen recognition of graft cells?
CTL
what cytokines are produced during the effector stage of graft rejection?
IL-2, IFN-gamma, TNF-beta
is IFN-gamma directly cytotoxic to graft cells?
no. TNF-beta is
what is IFN-gamma responsible for?
DTH response and recruitment of macrophages.
what cytokine is responsible for T cell proliferation and CTL activation?
IL-2
what type of rejection occurs after 2-4 weeks and is usually due to differences in classical MHC genes?
acute rejection
when does hyperacute rejection occur and what happens?
occurs within a few days after transplant. usually due to pre-existing antibodies (initiate complement activation) and or NK cells
what type of rejection will patients experience with: repeated blood transfusions, many pregnancies and previous graft?
hyperacute rejection
what type of rejection is due to minor histocompatibility antigens or the non-MHC genes? and can immunosuppressive drugs prevent it?
chronic rejection.
no immunosuppressive drugs cannot prevent it.
