thromobocytopenia

Question 1

what is thrombocytopenia

Answer 1

when you platelet count is less than 150k/microliter

Question 2

what are the three underlying causes of thromobocytopenia

Answer 2

underproduction, destruction, and sequestration.

Question 3

tell me about HIT

Answer 3

antibodies form complex with heparin and platelet specific PF4, 5-14 days after exposure. Patients die due to thrombosis usually,

Question 4

how do you diagnosis thromobocytopenia

Answer 4

careful history and physical exam, laboratory evaluation, bone marrow biopsy

Question 5

how do you manage thrombocytopenia

Answer 5

transfusion, corticosteroids, IVIG, plasmapheresis, splenectomy

Question 6

what are the indication for platelet transfusions

Answer 6

you do not do a transfusion in ITP or HIT, want it above 20k

Question 7

what is the normal platelet count

Answer 7

150-450k/microliter

Question 8

what is the main regulator for platelet production

Answer 8

thrombopoeitin from the liver regulates platelets

Question 9

what is the most common cause of underproduction

Answer 9

drugs and medications specifically chemotherapeutic and alcohol.

Question 10

what are the broad catagoreis of underproduction

Answer 10

congenital, nutritional deficiency, infectious, autoimmune, medications, malignancy, chronic hemolysis, granulomatous.

Question 11

what is panscytopenia

Answer 11

a decrees in RBC white and platelets