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CV II Exam 2 > Thrombosis I > Flashcards

Thrombosis I Flashcards

1
Q

primary hemostasis

A

platelet plug formation

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2
Q

secondary hemostasis

A

coagulation cascade

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3
Q

hemostasis sequence

A

endo injury/dysfunction - vasoconstriction

primary hemostasis

secondary hemostasis

antithrombotic activity

fibrinolysis

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4
Q

virchows triad

A

1 endo injury
2 prothrombotic state
3 abnormal flow

contribute to thrombosis
-endo most important - can cause other 2

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5
Q

economy class syndrome

A

stasis

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6
Q

hypercoagulability

A

antithrombin, protein C, protein S deficiency

protein C resistance - factor V leiden

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7
Q

Gp1b

A

platelets bind to vWF on endo via this receptor

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8
Q

GpIIbIIIa

A

platelets aggregate to one another by this receptor to fibrinogen

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9
Q

favor platelet aggregation

A

ADP and TxA2

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10
Q

factor XIII

A

important for cross linking of fibrin

-makes final clot strong

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11
Q

PGI2

A

inhibit platelet aggregation

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12
Q

protein C pathway

A

inhibit coagulation

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13
Q

heparin and antithrombin III

A

inhibit coagulation

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14
Q

tPA

A

finbrinolysis

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15
Q

plasmin

A

fibrinolysis

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16
Q

plasminogen activator inhibitor

A

inhibit fibrinolysis

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17
Q

alpha-2 antiplasmin

A

inhibit fibrinolysis

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18
Q

alpha-2 macroglobulin

A

inhibit fibrinolysis

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19
Q

vWF

A

binds GpIb

but also can bind GpIIbIIIa (bridge platelets)

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20
Q

intrinsic clotting pathway

A

XII > XIIa
XIIa: PK to K and XI > XIa
XIa: IX > IXa

IXa and VIIIa with Ca and phospholipid**
-results in X >Xa (to common pathway)

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21
Q

kallikrein

A

feedback to more XII > XIIa

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22
Q

extrinsic clotting pathway

A

Tissue factor + VII > VIIa

VIIa with calcium: X >Xa (to common pathway)

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23
Q

common clotting pathway

A

Xa, Va, calcium, and phospholipid
-results in II > IIa (prothrombin > thrombin)

IIa:many effects of thrombin

  • XI >XIa (intrinsic)
  • VIII > VIIIa (intrinsic)
  • V > Va (common)
  • XIII > XIIIa - with calcium
  • fibrinogen > fibrin - with calcium
24
Q

XIIIa

A

cross-linking of fibrin

25
TFPI
inhibit TF:VIIa complex from: - IX > IXa (extrinsic) - X > Xa (Ca dependent)
26
thrombin activity through PAR
PAR = protease activated receptor - induces TxA2 - platelet aggregation - activated endo cells - activates leukocytes
27
aPTT
measure of intrinsic pathway | -citrated plasma, Ca, phospholipid, activating surface (glass bead or kaolin)
28
PT
measure of extrinsic pathway | -citrated plasma, Ca, phospholipid, tissue factor
29
intrinsic tenase complex
on phospholipid surface - VIIIa and IXa - convert X > Xa
30
extrinsic tenase complex
on phospholipid surface - VIIa, TF, and Ca - convert X > Xa
31
prothrombinase complex
on phospholipid surface - Va and Xa - convert prothrombin > thrombin (II > IIa)
32
VIII
complexe with vWF in circulation
33
hageman factor
XII
34
christmas factor
IX
35
stuart-prower factor
X
36
labile factor
V
37
fibrinogen
I
38
fibrin
Ia
39
TT
thrombin time - measure of citrated plasma and thrombin - if think pt has fibrinogen problem
40
tissue factor
III
41
calcium
IV
42
factor VI
activated factor V
43
Vit K dependent factors
II, VII, IX, X | -no activated carboxylase groups
44
warfarin
affects Vit K dependent factors | 2, 7, 9, 10
45
unfractionated heparin
affects 12, 11, 9, 7, 10, 2
46
low MW heparin
fractionate | -affects only Xa
47
antithrombin
works on activated factors | IIa, Xa, VIIa, IXa, XIa, XIIa
48
Vit K
works on factor synthesis | 2, 7, 9, 10
49
factor VII deficiency
pro-thrombotic state | -problem with thrombosis
50
protein C and S
block amplification
51
clotting cascade in vivo
TF, Ca, VIIa - convert IX > IXa IXa and VIIIa: X > Xa Xa and Va: prothrombin > thrombin thrombin: fibrinogen > fibrin
52
thrombin effects
``` VIII > VIIIa XI > XIa V > Va fibrinogen > fibrin XIII > XIIIa ```
53
thrombomodulin
binds thrombin - which goes and activates protein C - active protein C and protein S result in proteolysis of factors Va and VIIIa
54
proteolysis of factors Va and VIIIa
end result of thrombomodulin
55
heparin like molecules
with antithrombin III _ inactivate thrombin and Xa and IXa
56
thrombin receptor
on endo cells -binds thrombin - causes endo release of PGI2, NO, adenosine diphosphatase - inhibitors of platelet aggregation - also cause release of tPA - initiate fibrinolysis

CV II Exam 2 (18 decks)

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