Pathology of the Heart V Flashcards
trypanosomes
in chagas disease
intracellular accumulations in myocardial cells
lower ejection fraction
in dilate cardiomyopathy
alcohol, pregnancy, myocarditis
impaired compliance - diastolic dysfunction
in hypertrophic and restrictive cardiomyopathy
proteins in dilated cardiomyopathy
anchoring proteins - cytoskeletal proteins
desmin, ystrophin, elta sarcoglycan
proteins in hypertrophic cardiomyopathy
myosin binding protein C
myosin light chains
sarcomere proteins
proteins and dilated and hypertrophic cardiomyopathy
beta-myosin heavy chain
-chromosome 14**
dilated cardiomyopathy
myocarditis - coxsacike B alcohol - acetaldehyde toxic peripartum - late in pregnancy -iron overload -genetic mutation in titin (TTN) auto dominant
leads to CHF***
common indication for cardiac transplant
all chambers dilate
arrhythmogenic right ventricular cardiomyopathy
right V dysplasia - replace by fat collagen
young person, heart problems, right V all fatty
-get arrhythmias
mutations in plakoglobin and desmoplakin
plakoglobin and desmoplakin
mutated in arrhythmogenic right ventricular cardiomyopathy
most have auto dominant mutation
naxos syndrome
arrhythmogenic right ventricular dysplasia
AND palmoplantar keratoderma, wooly hair
recessive plakoglobin mutation
hypertrophic cardiomyopathy
ALL GENETIC myocardial hypertrophy -abnormal diastolic filling -exertional dyspnea -atrial fib maybe -can get dilated atrium
physical activity of young person - drops dead
beta myosin heavy chain mutation - Chromsome 14
sudden death
boxcar nuclei
restrictive cardiomyopathy
decreased ventricle compliance
-biatrial enlargement
often with:
- amyloidosis
- endomyocardial fibrosis
- loeffler endomyocarditis - eisinophil infiltrate
- endocardial fibroelastosis
transthyretin
mutation in amyloidisis
-can lead to restrictive cardiomyopathy
amyloidosis
congo red stain - apple-green befringement
myxoma
mucoid tumor of cardiac tissue
-attach to fossa ovalis in left atria
number one primary heart tumor in children
rhabdomyoma
tuberous sclerosis
spider cells
carney complex
myxomas, pigmented skin lesions, and overactive endocrine organs
pericardial effusions
serous - CHF, hypoalbuminemia seroanguinous - malignancy, trauma, rupture MI, aortic dissection sanguinous - hemopericardium purulent - infection chylous - lymph blockage malignant
can result in cardiac tamponade
number one case of pericarditis
renal failure - serous fluid - fibrinous
dressler syndrome
post MI
can be cause of serous pericarditis
TB
associated with hemorrhagic pericarditis
-as well as caseous
rheumatic fever
associated with serous pericarditis
allograft arteriopathy
concentric intimal thickening with stenosis
