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Hematology > Thrombopoiesis > Flashcards

Thrombopoiesis Flashcards

1
Q

CFU-GEMM → CFU-Meg →

A

Megakaryoblast → Megakaryocyte → Thrombocyte (platelets)

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2
Q

Thrombopoiesis / megakaryoctyopiesis is stimulated by

A

Thrombopoeitin

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3
Q

Between Megakaryoblast and megakaryocte

A

promegakarycote

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4
Q

As megakaryocytic cell matures…

A

Cell volume increases (different than any other cell line) - till fragmented

NC ratio decreases

Chromatin - condenses

Nucleoli - disappear

Undergoes endomitosis → nuclear material continuously doubles without dividing, resulting in polyploid nucleus

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5
Q

Megakaryoblast

A

Cytoplasm: pseudopodia present (ONLY class with these ) + non granular

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6
Q

Promegakaryocyte

A

Cytoplasm → pseudopodia + fine azurophilic granules

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7
Q
A

promegakaryocyte

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8
Q
A

Megakaryocyte (w/ platelets)

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9
Q
A

megakaryocyte (w/o platelets)

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10
Q

Megakaryocyte

size

Nucleus

Cytoplasm

NC

BM

A

size → 30-100 micro m

Nucleus → central and +2 lobules. blue/purple. granular, no nucleoli

Cytoplasm → pale/blue pink. Numerous azurophilic granules

NC → 1:1 - 1:2

BM

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11
Q

PLTs breaking off

A

metamegakaryocyte

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12
Q
A

platelet/thrombocyte

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13
Q
A

thrombocyte / platelet

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14
Q
A

thrombocyte/platelet

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15
Q

thrombocyte/platelet

size

Nucleus

Cytoplasm

granulomere

A

size → 1-4 micro m

Nucleus → none

Cytoplasm → light blue. reddish-blue granules

granulomere → central portion / red granules

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16
Q

hyalomere

A

pale portion/ the clearing area/ not refractive of a platelet/ thrombocyte

17
Q

Platelets form _______ _____ between each other in megakaryocyte

A

demarcation membranes

18
Q

30% of platelets sequestered in ___ as reserve

A

spleen

19
Q

aged or dead platelets are removed by ___ and ___; similar system as RBC

A

spleen and liver

20
Q

platelets are individual ___ ____ released into peripheral blood

A

cytoplasmic fragment

21
Q

platelets circulate

A

9-12 days

22
Q

platelets contain chemicals that function to:

A
  1. maintain blood volume integrity
  2. initiate homeostasis
  3. promote coagulation - provide a template to grow clot on and initiating other clotting factors
23
Q

when vessel or tissue is damaged, the platelets

A

change shape, become clumpy and sticky (primary homeostasis)

24
Q
A

osteoclasts

(separated nuclei)

25
Q

Osteoclasts (macrophage in bone)

size

Nucleus

Function

NC

BM

A

size: >100 micro m

Nucleus - 2-50 separated nuclei with visible nucleoli

Function → absorption of bone

NC

BM

Hematology (36 decks)

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