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Hematology > Monopoiesis > Flashcards

Monopoiesis Flashcards

1
Q

CFU-GEMM → CFU-GM - CFU-M

A

monoblast → promonocyte →. monocyte > macrophage

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2
Q

As monocytic cell develops ..

A
  • Cell volume slightly decreases
  • NC ratio decreases
  • Chromatin stays fine
  • Nucleoli disappear

After maturation, it can move into the tissue and expand, becoming a macrophage

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3
Q

Monocytes are increased in:

A

mumps (viral infection)

Intracellular bacterial infections → tuberculosis, legionella, salmonella

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4
Q

Monoblast

size

Nucleus

Cytoplasm

NC

BM

A

size → 15-25 micro m

Nucleus → round, oval. chromatin is fine, pale, threadlike. Nucleoli

Cytoplasm → moderate/ basophilic

NC → 7:1-4:1

BM → 0-1%

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5
Q

Promonocyte

size

Nucleus

Cytoplasm

NC

BM

A

size

Nucleus - Peaked crease

Cytoplasm

NC

BM

Last stage of mitotic divison

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6
Q
A

Promonocyte

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7
Q

Maturation differences b/w monoblast and promonocyte

A
  • Chromatin stays fine, but shifts from thread like to reticular pattern
  • Prominent crease forms
  • More cytoplasm with paler color
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8
Q
A

Promonocytes

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9
Q

Mature Monocyte

size

Nucleus

Cytoplasm

NC

BM

A

size

Nucleus → Convolutions/different shapes. Lacy chromatin. No nucleoli

Cytoplasm → ground glass, vacuoles may appear

NC

BM

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10
Q
A

Monocyte

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11
Q
A

Monocyte

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12
Q
A

Monocyte

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13
Q
A

promonocyte

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14
Q
A

monocyte

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15
Q
A

Macrophage

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16
Q

Monocytes move into tissue and become

A

macrophages. They do not normally re-enter blood stream, but can during inflammation

17
Q

A fixed (non-motile) macrophage is termed

A

histiocyte

18
Q
19
Q
20
Q

What is a tart cell?

A

phagocytic cell engulfing at least the nucleus of another cell (also when engulfing an entire RBC). If nuclear material stays intact with normal staining features - not digested.

21
Q

Macrophage function:

A
  1. Phagocytosis
  2. Antigen presentation
  3. Secretion
22
Q

Phagocytosis - Liver

A

Kupffer Cells

23
Q

Phagocytosis - lungs

A

Alveolar macrophages

24
Q

phagocytosis - bone

A

osteoclasts

25
Q

phagocytosis - skin and mucosa

A

langerhans cell

26
Q

Secretion of cytokines by macrophages

A
  • induce fever
  • complement
  • capillary growth factors
  • chemotactic factors
  • stimulating factors
27
Q

Antigen presentation

A

Macrophage ingest something with foreign antigen. Ingest the particle, but “foreign” parts are preserved. Foreign parts are mixed with macrophage RNA. Mixture is then brought to cell’s surface

Hematology (36 decks)

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