Thrombophilia Flashcards
1
Q
What is a thrombophilia?
A
An inherited or acquired coagulopathy that predisposes to thromboembolism.
2
Q
What is the most common inherited thrombophilia?
A
Factor V Leiden/Activated protein C deficiency
3
Q
Explain what factor V Leiden does:
A
- Single point mutation of factor V
- Means factor V isn’t broken down by activated protein C
4
Q
What is the diagnostic investigation for factor V Leiden?
A
APC resistance test
5
Q
What is the second most common thrombophilia?
A
Prothrombin gene mutation
6
Q
What protein deficiencies cause thrombophilias?
A
- Antithrombin III deficiency
- Protein C deficiency
- Protein S deficiency
7
Q
What are causes of acquired thrombophilias?
A
- Antiphospholipid syndrome
- COCP/HRT
- Thrombocytosis
- Polycythaemia
