Antiphospholipid syndrome

Question 1

What are the features of antiphospholipid syndrome?

Answer 1

CLOTS
C - Coagulation defect (arterial/venous)
L - Livedo reticularis (purple mottled skin)
O - Obstetric (recurrent miscarriage, IUGR, pre-eclampsia, placental abruption, VTE)
T - Thrombocytopenia

Question 2

How do you manage APS in pregnancy?

Answer 2

1. Low dose aspirin as soon as pregnancy is confirmed

2. LMWH once fetal heart is seen on USS until 34 weeks

Question 3

What does APS commonly occur with?

Answer 3

SLE