Thrombolytics

Question 1

Thrombolytics: Common Drugs

Answer 1

Alteplase (tPA), Reteplase, Tenecteplase

Question 2

Thrombolytics: Mechanism of Action

Answer 2

Converts plasminogen to plasmin, which degrades fibrin clots, fibrinogen, and other plasma proteins.

Question 3

Thrombolytics: Indications

Answer 3

Acute myocardial infarction (AMI), ischemic stroke, pulmonary embolism, and deep vein thrombosis.

Question 4

Thrombolytics: Contraindications

Answer 4

Active internal bleeding, recent surgery, history of hemorrhagic stroke, severe uncontrolled hypertension.

Question 5

Thrombolytics: Safety Considerations

Answer 5

Monitor for signs of bleeding, maintain bed rest, avoid invasive procedures, frequent neurological assessments.

Question 6

Thrombolytics: Administration Considerations

Answer 6

Administer IV with close monitoring in a critical care setting, ensure baseline coagulation studies before administration.

Question 7

Thrombolytics: Adverse Effects

Answer 7

Hemorrhage, allergic reactions, hypotension, reperfusion arrhythmias.