Thoracic

Question 1

What defines limited stage SCLC

Answer 1

• limited to hemithorax
• can be covered safely with RT fields

Question 2

Front line tx for SCLC extensive stage

Answer 2

-Carbo
- Etop
- PDL1 (atezo or durva)

Question 3

Second line SCLC tx

Answer 3

• Lurbinectidin

-Topitecan

• retrial platinum (if >6m)

Question 4

Who gets primary surgery for SCLC

Answer 4

T1-2, N0

Question 5

Who gets neoadjuvant chemo for SCLC

Answer 5

N+ OR T3+ (5cm)

Question 6

What is adjuvant tx for resected SCLC

Answer 6

• cis /etop x4
• concurrent RT (60-70Gy)

-WBRT ppx

Question 7

NSCLC Actionable mutations

Answer 7

1 - EGFR - osi
2 - ALK - Alectinib, brigatinib, loralatinib
3 - ROS1 - entrectanib, crizotinib
4 - MET - capmantinib
5 - NTRK - entrectonib / larotrectinib
6 - RET - selpercaptinib
7 - BRAF - Dabi / tram

Question 8

Second line NSCLC after chemo - IO

Answer 8

Docetaxel + ramicirumab

Question 9

Mesothelioma tx

Answer 9

Epithelial - carbo / pemetrexed +/- Bev or durva

Sarcomatoid - IPI / nivo

Question 10

ROS1 NSCLC

Answer 10

Crizotinib / entrectanib

Question 11

Adjuvant therapy after definitive CRT for NSCLC

Answer 11

Durvalumab

Question 12

Adjuvant therapy after surgery for NSCLC

Answer 12

Atezolizumab

Question 13

Second line thymoma treatment

Answer 13

Pemetrexed