Head and Neck Flashcards
Who gets RAI for differentiated thyroid CA (4)
- LVI
- M1
- N+
- R1 resection
First line therapy for Medullary thyroid CA
1) surgical resection
2) RETmut - selpercatinib
3) RETwt - cabozantanib
Second line dacarbazine based chemo
Treatment for Anaplastic thyroid CA (2)
IVA -> surgery / chemo RT
IVb/c -
BRAFmut - BRAF/MEK
BRAFwt - chemo RT
Treatment for nasopharyngeal CA
T1 -RT
T2-4,N1-3 - cis gem then CRT with cis
What is T1 for NPC?
Nasal confined or extension only to oral cavity without other invasion
Treatment for hypopharynx cancer (laryngeal)
T1 - RT or partial laryngectomy
T2-4a,N0-3 - anything goes (TPF > RT or Surgery or CRT)
What is T4b head and neck CA ? And how is it treated
T4b is essentially unresectable disease with involvement of the skull base, carotid, or vertebral space
It is treated with non invasive definitive CRT or RT alone in PS2 patients
Oropharyngeal CA treatment
T1-2, N0-1 - Surgery or RT
T3-4, N2-3 - CRT
CRT regimen for HN CA
cos 100mg/m2 q3w
Induction regimen for NPC
Cis-Gem
Metastatic HN CA Tx
1) pembro
2) pembro - platinum - 5FU
3) cetux - platinum - 5FU
Types of NP cancer
I - keritinizing
II - non keritinizing / differentiated
III - non keritinizing / undifferentiated/ EBV
Salivary Gland Cancer tx
1) surgery
2) adjuvant RT if high grade / PNI / N+
Common types of salivary tumors
Pleimorphic adenona - benign
Salivary ductal carcinoma - high grade
Mammary analog secretory carcinoma - high grade
Testing in salivary gland tumors
- MACS - NTRK
- Salivary ductal CA - HER2 / androgen receptor
