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Oncology > GI > Flashcards

GI Flashcards

1
Q

What is the relationship of BRAF to Lynch syndrome

A

They are mutually exclusive

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2
Q

What is the relationship of MSI to BRAF in CRC

A

They are mutually exclusive

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3
Q

Molecular testing needed for m1 colon adenocarcinoma

A
  • PDL1
  • BRAF / MSI /
  • HER2
  • TMV
  • KRAS / NRAS
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4
Q

Sidedness
-RAS/RAF
-bev responsiveness
- EGFR responsiveness

A

R>L RAS/RAF
R>L. bev responsiveness
L>R. EGFR responsiveness***

*** response seen when RAS/RAF wt

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5
Q

First line m1 colon adenocarcinoma

A

1 - FOLFOX / FOLFIRI
+/- Bev

3 - FOLFOXIRI - convert to respectability

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6
Q

Second line M1 colon adenocarcinoma

A

PDL1 / TMB high - pembro
Low&raquo_space; molecular
- BRAF
- HER2

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7
Q

Third line colon adenocarcinoma

A

Lonsurf
Regorafenib

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8
Q

Define adjuvant therapy for colon CA based on T and N status

A

T1-3, N0 - Stage IIA - none
T4 N0 - stage IIB/C - 5FU/ leucovorin
Tx N1 - stage III - 6m FOLFOX / CAPOX

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9
Q

What stage II CRC doesn’t get ADJ tx? (3)

A
  • patient preference
  • T1-3
  • MSI HIGH
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10
Q

Surface markers for GIST

A

cKIT (CD117) / DOG1

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11
Q

Staying for GIST requires….

A
  • size
  • location
  • mitoses / 50HPF
  • Nodes
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12
Q

What is the implication of node positive GIST

A

Metastatic/ stage 4 disease

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13
Q

Role for adjuvant TKI in GIST

A

high risk patients (5cm AND high motoring rate)

Tx with three years of therapy

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14
Q

Subsequent therapies in GIST

A

Sunitinib
Regorafinib
Ripretinib

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15
Q

Mutation that confers Imari in resistance in GIST

A

PDGFRA D842V (exon 18)

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16
Q

Treatment of non canonical GIST (cKit and PDGFRA negative)

A

Sunitinib

17
Q

Pancreatic CA germline testing

A
  • BRCA
  • PALB2
  • ATM
  • STK11
  • MLH1/2 MSH6
  • CDNK2D
18
Q

HPV variant with Anal SCC

A

HPV 16

19
Q

Tx for non metastatic Anal SCC

A

CRT
- 5FU CIV 1-4,29-32
- mitomycin 1,29
RT
-50-54Gy
-42-45 fx

20
Q

CholangioCA adjuvant tx

A

Cape

21
Q

Tx for unresectable CholangioCA

A

Durva - gem-cis up to 8 cycles

22
Q

All CholangioCA should be tested for

A

1 - IDH1 and FGFR2
2- full foundation panel given rare NTRK RET TMB HER2 etc

23
Q

HCC criteria for transplant

A

AFP< 1000
AND
one tumors <5cm
Or
3 tumors <3cm

24
Q

First line unresectable HCC tx (3)

A
  • atezo bev
  • treme durva
  • sorafinib (contra indication for checkpoint)
25
Q

Second like HCC

A
  • Cabo / lenvatinib / regorafinib
26
Q

RAPIDO trial findings

A

TMT with short course and long course CRT has similar OS but short course RT has less recurrent disease st 3 years

Oncology (10 decks)

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