CNS Flashcards
1
Q
Classic mutation in non GBM CNS glioma
A
1p19q
Positive prognostic factor
2
Q
IDH mutations in CNS disease
A
1) GBM - IDHwt
2) Astrocytoma / Oligodendroma - IDHmut
3
Q
What is the prognostic implication of MGMT methylation in GBM?
A
Temozolomide sensitivity
- 12 v 24m Median OS
4
Q
Classic mutation profile of GBM, oligodendroglioma and astrocytoma
A
- GBM - IDHwt
- ODG - IDHmut / del 1p19q
- ASTRO - IDHmut / P53mut / ATRXmut
5
Q
Tx for non GBM glioma
- grade 2 and 3
A
2
Total resection > non
Subtotal > RT + Tem or PCV
3 > RT + Tem or PCV
6
Q
GBM Tx algorithm
A
1- maximal resection
2- adjuvant RT +Tem
3- adjuvant Tem x 6-12m
7
Q
Primary CNS lymphoma consolidation options (3)
A
- thiotepa auto
- WBRT
- etoposide / ara C
8
Q
PCNSL induction
A
MTX 8g/m2 and rituxan
9
Q
R/R GBM treatment
A
Lomustine
