Cutaneous onc

Question 1

Basal cell CA
Lines 1-2

Answer 1

1) hedgehog inhibitors (sonidegib, vismedegib)
2) PD1 - cemiplimab

Question 2

Merckel cell unknown primary risk is …

Answer 2

Lower thank known primary (improved immune surveillance)

Question 3

Metastatic Merckel cell tx lines 1-3

Answer 3

1) pembro / avelumab
2) IPI and nivo
3) carbo etop

Question 4

Tx or local Merckel Cell

Answer 4

1) WLE
2) SLNB
3) if positive ADJ RT

Question 5

Metastatic Uveal melanoma tx

Answer 5

Tebentafusp (gp100 target)

Question 6

Systemic treatment for bone sarcomas
- Giant cell
- Chordoma
- Chondrosarcoma
- Ewing
- osteosarcoma

Answer 6

• Giant cell - denosumab
• Chordoma - Imatinib
• Chondrosarcoma - Dasani in / Pasopinib
• Ewing - VDC/IE
• osteosarcoma - cis/doxo or MAP