Thiazide Diuretics Flashcards
What are common indications for thiazide diuretics?
- Alternative first line for HTN
- Add-on treatment HTN
What is the mechanism of action of thiazide diuretics?
Inhibit the Na+/Cl− co-transporter in the distal convoluted tubule of the nephron. This prevents reabsorption of sodium and water
What section of the nephron do thiazide diuretics act on?
Distal convoluted tubule
What are adverse side effects of thiazide diuretics?
- Hyponatraemia
- Hypokalaemia
- Increased glucose
- Increased LDL-cholesterol
- Increased triglycerides
- Impotence
When are thiazides contraindicated for use?
Hypokalaemia
What dose of bendroflumathiazide might you start someone on for treating hypertension?
2.5 mg daily in the morning
What dose of bendroflumathiazide would you start someone on for treating HF?
2.5-5 mg daily
What dose of bendroflumathiazide would you start someone on for treating oedema?
5-10 mg daily in the morning
What dose of indapamide might you start someone on for treatment of hypertension?
2.5 mg
What are examples of thiazide diuretics?
- Bendroflumathiazide
- Indapamide
- Clortalidone
Why can using ACEi and thiazide diuretics together be very useful for treating hypertension?
Can lower BP plus maintain neutral potassium balance due to their opposite effects on potassium levels
