5alpha-reductase inhibitors Flashcards
1
Q
What are indications for using 5-alpha-reductase inhibitors?
A
BPH
2
Q
What is an example of 5=alpha-reductase inhibitor?
A
Finasteride
3
Q
How do 5alpha-reductase inhibitors work?
A
Inhibit the intracellular enzyme 5alpha-reductase, which converts testosterone to its more active metabolite dihydrotestosterone. This stimulates prostatic growth, and thus its effects are blocked by 5a-reductase inhibitors
4
Q
Why are alpha blockers used as first line for treating BPH?
A
Due to the length of time it takes for 5a-reductase inhibitors to work - can take several months
5
Q
What are adverse side effects of 5a-reductase inhibitors?
A
- Impotence
- Reduced libido
- Gynaecomastia
- Hair growth
- Breast cancer
6
Q
When should 5a-reductase inhibitors not be prescribed?
A
Pregnancy - can cause male foetus to develop abnormal genetalia
