Potassium-sparing Diuretics Flashcards
1
Q
What are common indications for potassium sparing diuretics?
A
As part of combination therapy - for treatment of hypokalaemia arising from loop/thiazide diuretics
2
Q
What are examples of potassium sparing diuretics?
A
Amiloride
3
Q
What is the mechanism of action of potassium-sparing diuretics?
A
In combination with other diuretics, theycounteract potassium loss and enhance diuresis. Amiloride acts on DCT, inhibiting reabsorption of Na+, leading to Na+ and water excretiuon and K+ retention
4
Q
What are important adverse effects of amiloride?
A
- GI upset
- Dizziness
- Hypotension
- Urinary symptoms
- Electrolyte disturbance - hypo/hyperkalaemia, hyponatraemia
5
Q
When is using amiloride contraindicated?
A
- Severe renal impairment
- Hyperkalaemia
6
Q
What is the most commonly used forumlation of amiloride?
A
Combination therapy - loop or thiazide diuretics
- Co-amilofruse
- Co-amilozide
7
Q
What monitoring should you consider doing when using amiloride?
A
U+E’s
