Antimuscarinics

Question 1

What are examples of antimuscarinic medicines used for GU problems?

Answer 1

• Oxybutinin
• Tolteridone
• Solifenacin

Question 2

What are indications for the use of antimuscarinics in the GU system?

Answer 2

Reduce urinary frequency from overactive bladder

Question 3

What is the mechanism of action of antimuscarinics used for overactive bladder?

Answer 3

Competitive inhibitor of acetylcholine. Contraction of the bladder is under parasympathetic control - bloackade promotes relaxation, increasing bladder capacity, reducing urinary frequency, urgency and urge incontinence

Question 4

What is the main muscarinic receptor subtype of the bladder?

Answer 4

M3

Question 5

What are side effects of antimuscarinics?

Answer 5

• Dry mouth
• Tachycardia
• Constipation
• Blurred vision
• Urinary retention

Question 6

When are antimuscarinics contraindicated when used to treat urinary incontinence?

Answer 6

UTI

Question 7

What is an important part of assessment before prescribing antimuscarinics in someone with urinary problems?

Answer 7

Urine dipstick

Question 8

What groups of drugs should you be cautious prescribing antimuscarinics in?

Answer 8

Others with antimuscarinic effects

Question 9

When would you prescribe antimuscarinics for urge incontinence?

Answer 9

After attempted bladder retraining