Thermodynamic basis of drug action

Question 1

Drug doesn’t have to be in solution to enter systemic circulation. True or false?

Answer 1

False

Question 2

Drugs need to be dissolved to enter GIT. True or false?

Answer 2

True

Question 3

Membrane of GIT is lipophilic. True or false?

Answer 3

True

Question 4

Metabolism predominantly occurs in the kidney. True or false?

Answer 4

False - liver

Question 5

Which proteins are predominantly involved in phase one metabolism of drugs in the liver?

Answer 5

CYP450

Question 6

Why are lipophilic drugs more likely to be cleared?

Answer 6

Because they don’t have strong interactions with water and so water molecules will organise themselves around drug and push it into any protein they can find i.e. CYP and so drug is metabolised

Question 7

What is the range that lipophilicity of drugs are aimed to be?

Answer 7

0- 3.5

Question 8

A drug with a lipophilicity of below zero is orally administered. True or false?

Answer 8

False