Therapies Flashcards
how can the inflammatory system help metatasis
by flagging where escaping tumour cells can live
what diseases provide more of an opportunity for cancer development
inflammatory diseases
what type of signals do inflammatory diseases send out
proliferating signals
how big can a tumour grow without a microenvironment
no bigger than 3mm
what is a TAM
tumour associated macrophage
what is MDSC
myeloid derived suppressor cells
what do MDSC’s do? can we target them
stop anti tumour response
yes they are very good to target
which cells can we enhance for anticancer therapy
t-cell anti tumour response
why does tobacco promote lung cancer formation?
induces inflammation which provides a good environment
in terms of inflammation what must the tumour do
avoid immune destruction- surface expression of cancer cells increase which act like red flags to the body
does immunodeficiency increase cancer risk? think mice
yes, get a higher percentage of mice with tumours in a shorter time if they dont have T-cells after being injected with a carcinogen
when you have functioning T-cells the tumour grows _____
slower
can we have a tumour and not know about it?
yes the body could eliminate it before you get symptoms
can be in a balance of tumour inflammation and anti tumour inflammation for years before a mutation for example pushes it to grow
name factors which can push the balance towards pro tumourigenic inflammation?
genetic instability
selection pressure- loss of red flags on the cell
repression of autoimmunity - tumour switches off the anti tumour inflammatory response
what can the tumour secrete to switch off the anti tumour response?
IL10, TGFB, IFNY
