EGFR targeting Flashcards
TF: signalling through HER1,2,3,4 is ligand independent
false
2 EGFR pathways?
MAPK pi3k
lapatinib is commonly known as a _____ inhibitor
HER2
How do antibodies work in blocking kinase activity?
prevent GF binding or chance receptors appearance to stop GF binding
____% of breast cancers are HER2 positive
30%
HER2 positive is associated with what?
more aggressive disease
small molecule approaches to HER2? DRUG NAME
laptanib
binds HER2 at high levels
antibody approaches to target HER2? DRUG NAME
Trastuzumab
Pertuzumab
can also do a combination of these two
what does HER2 over activation do?
activates all pathways leading to proliferation e.g. MAPK PI3K, RAS
3 Pathways which HER2 over activation increases
MAPK PI3K and RAS
What does AB and small molecule inhibitors binding on the surface stop?
downstream signalling
Herceptin in combination with taxol is approved first line for?
treatment of HER2 metastatic breast cancer
Herceptin alone is approved for?
HER2 breast cancer in patient who have received one or more chemotherapy courses for metastatic disease
beside breast cancer what else can Herceptin treat?
gastic cancer in combination therapy
in patient who have been prescribed treatment for metatstatic disease
TF: combination of 2 HER2 targeting antibodies is good
TRUE
