Targeting downstream of RTK's

Question 1

_____ cancers overexposes HER2 than EGFR

more or fewer

Answer 1

FEWER

Question 2

over expression of EGFR the ____ the probability of you surviving for longer

Answer 2

lower

Question 3

what is cetuximab

Answer 3

antibody which binds to and inhibits the EGFR

Question 4

cetuximab is commonly used in ______ therapy with _______

Answer 4

combination

radiation

Question 5

normally EGFR is part of a negative ______ ______

Answer 5

feedback loop

Question 6

why can a KRAS mutation stop EGFR inhibitors working?

Answer 6

hyper activated downstream of the receptor- doesn’t matter if its blocked

Question 7

what is cetuximab licensed in?

Answer 7

large bowel cancer and head and neck cancer

Question 8

cetuximab in bowel cancer: how is it used?

Answer 8

in combination with chemotherapy

Question 9

what must you screen for before giving EGFR inhibitors?

Answer 9

K-ras mutation

Question 10

cetuximab in head and neck cancer: how is it used?

Answer 10

in combination with radiotherapy

Question 11

why was over expression of EGFR not enough to identify responsiveness to small molecule EGFR inhibitors?

Answer 11

sub analysis showed that patients who responded to small molecule inhibitors had mutated EGFR