Therapeutics Flashcards

1
Q

Which drugs are P450 enzyme inducers

A
Carbamazepine
Rifampicin
bArbiturates
Phenytoin
St John's Wort
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2
Q

Which drugs are P450 enzyme inhibitors

A

Some certain silly compounds annoyingly inhibit enzymes, grrr

Sodium valproate
ciprofloxacin
sulphonamide
Cimetidine/omeprozole
Antifungals, amiodarone
Isoniazid
Erythromycin/clarithromycin
Grapefruit juice
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3
Q

Which drugs are affected by P450 metabolism

A
warfarin
COCP
theophylline
corticosteroids
tricyclics 
pethidine 
statins
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4
Q

Name some drugs with narrow therapeutic ranges

A
lithium
digoxin
gentamicin
warfarin
methotrexate
theophylline
phenytoin
insulin
ciclosporin
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