Therapeutic Proteins Flashcards

1
Q

Abbreviation for humanized source

A

Zu

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2
Q

Name 3 disadvantages of cytokine treatments

A
  1. Short t1/2
  2. Potent
  3. Compliacated cascade = less predictibility
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3
Q

Nomenclature order of Therapeutic proteins

A

[Drug Company Choice] [target][source] MAB

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4
Q

2 strategies of antibody therapy?

A
  1. inhibit protein function/block receptor

2. recruit immune system to attack targetq

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5
Q

Advantage of Peg-ylated proteins

A

Longer half life and mask protein from immune system

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6
Q

Describe Hypersensitivity I

A

Immediate and gets worse with repeated administration

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7
Q

Describe Type III Hypersensitivity

A

Slow response and with repeated exposure response lessens

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8
Q

List side effects of antibody treatment

A
Type III Hypersensitivity
HAMA response
Serum Sickness
Infusion reaction
Cytokine Release Syndrome
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9
Q

This Protein has the shortest half-life of all therapeutic proteins

A

TNF

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10
Q

Most important feature in antibody therapy

A

Specificity

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11
Q

Which antibodies stimulate RBC prodution

A

Darbepoeitin
Erythro
MPEG-e

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12
Q

Which hematopoetic agents can cause A-fib?

A

Il-11

Romiplastin

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13
Q

Describe Sagramostim

A

Myeloid stimulus which causes capillary leak, eduema and stimulates granulocytes

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14
Q

This drug stimulates production fo neutrophils

A

Filgrastim (G-CSF)

PEF-filgrastim`

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