Therapeutic Proteins Flashcards
Abbreviation for humanized source
Zu
Name 3 disadvantages of cytokine treatments
- Short t1/2
- Potent
- Compliacated cascade = less predictibility
Nomenclature order of Therapeutic proteins
[Drug Company Choice] [target][source] MAB
2 strategies of antibody therapy?
- inhibit protein function/block receptor
2. recruit immune system to attack targetq
Advantage of Peg-ylated proteins
Longer half life and mask protein from immune system
Describe Hypersensitivity I
Immediate and gets worse with repeated administration
Describe Type III Hypersensitivity
Slow response and with repeated exposure response lessens
List side effects of antibody treatment
Type III Hypersensitivity HAMA response Serum Sickness Infusion reaction Cytokine Release Syndrome
This Protein has the shortest half-life of all therapeutic proteins
TNF
Most important feature in antibody therapy
Specificity
Which antibodies stimulate RBC prodution
Darbepoeitin
Erythro
MPEG-e
Which hematopoetic agents can cause A-fib?
Il-11
Romiplastin
Describe Sagramostim
Myeloid stimulus which causes capillary leak, eduema and stimulates granulocytes
This drug stimulates production fo neutrophils
Filgrastim (G-CSF)
PEF-filgrastim`